CAJ | 학술논문

目的：探讨含呋喃唑酮方案对幽门螺杆菌（Hp）感染的十二指肠溃疡患者 Hp根除效果，以降低 Hp感染率。方法选取2010年3月－2014年3月 H p阳性十二指肠溃疡患者252例为研究对象，将患者按照不同治疗方案分为观察组和对照组，观察组给予含呋喃唑酮方案治疗，对照组给予不含呋喃唑酮的方案治疗，对比两组患者的H p根除率、临床缓解情况、不良反应。结果观察组H p根除率89．88％，高于对照组的77．38％，两组差异有统计学意义（P＜0．01）；观察组临床症状缓解效果优于对照组，差异有统计学意义（P＜0．05）；两组均未出现严重不良反应，观察组和对照组不良反应发生率差异无统计学意义。结论含呋喃唑酮方案可以提高 Hp阳性十二指肠溃疡的 Hp根除率，增强患者临床症状缓解效果，且安全性较高。
목적：탐토함부남서동방안대유문라간균（Hp）감염적십이지장궤양환자 Hp근제효과，이강저 Hp감염솔。방법선취2010년3월－2014년3월 H p양성십이지장궤양환자252례위연구대상，장환자안조불동치료방안분위관찰조화대조조，관찰조급여함부남서동방안치료，대조조급여불함부남서동적방안치료，대비량조환자적H p근제솔、림상완해정황、불량반응。결과관찰조H p근제솔89．88％，고우대조조적77．38％，량조차이유통계학의의（P＜0．01）；관찰조림상증상완해효과우우대조조，차이유통계학의의（P＜0．05）；량조균미출현엄중불량반응，관찰조화대조조불량반응발생솔차이무통계학의의。결론함부남서동방안가이제고 Hp양성십이지장궤양적 Hp근제솔，증강환자림상증상완해효과，차안전성교고。
OBJECTIVE To explore the effect of furazolidone containing program on eradication of Helicobacter py‐lori in patients with duodenal ulcer so as to reduce the incidence of H .pylori infection .METHODS From Mar 2010 to Mar 2014 ,a total of 252 duodenal ulcer patients tested positive for H .pylori were recruited as the study objects and divided into the observation group and the control group .The observation group was treated with furazolidone containing program ,while the control group was given furazolidone‐free containing program ;the eradication rate of H .pylori ,status of clinical remission ,and adverse reactions were observed and compared between the two groups .RESULTS The eradication rate of H .pylori of the observation group was 89 .88% ,significantly higher than 77 .38% of the control group(P< 0 .01) .The observation group was significantly superior to the control group in the effect of remission of clinical symptoms(P<0 .05) .Severe adverse reactions occurred in neither of the two groups ,and there was no significant difference in the incidence of adverse reactions between the observation group and the control group .CONCLUSION The furazolidone containing program can raise the eradication rate of H .pylori in the patients with duodenal ulcer and intensify the effect of remission of clinical symptoms ,with the safety high .