中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
13期
34-35
,共2页
雷公藤多苷%糖尿病肾病%蛋白尿
雷公籐多苷%糖尿病腎病%蛋白尿
뢰공등다감%당뇨병신병%단백뇨
Tripterygium glycosides%Diabetic nephropathy%Proteinuria
目的：探讨雷公藤多苷治疗糖尿病肾病蛋白尿期的疗效及治疗前后炎性因子水平，初步探讨其机制。方法：2014年1-7月收治糖尿病肾病蛋白尿期患者40例，按照数字随机法分为观察组和对照组各20例。对照组给予常规降血糖药物治疗，试验组在常规治疗的基础上给予雷公藤多苷片。用药10周后，比较两组患者治疗前后蛋白尿缓解情况以及肾功能、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)水平变化。结果：观察组完全缓解5例，有效10例，无变化5例；对照组完全缓解1例，有效3例，无变化16例；观察组24 h蛋白尿缓解率高于对照组，差异具有统计学意义(P＜0.05)。观察组24 h尿微量白蛋白、BUN、Scr较治疗前显著降低(P＜0.05)，与对照组治疗后比较差异有统计学意义(P＜0.05)。观察组TNF-α、CRP较治疗前显著降低(P＜0.05)，且显著低于对照组(P＜0.05)。结论：雷公藤多苷可降低糖尿病肾病患者体内炎性反应，减少24 h尿蛋白，且不良反应较小。
目的：探討雷公籐多苷治療糖尿病腎病蛋白尿期的療效及治療前後炎性因子水平，初步探討其機製。方法：2014年1-7月收治糖尿病腎病蛋白尿期患者40例，按照數字隨機法分為觀察組和對照組各20例。對照組給予常規降血糖藥物治療，試驗組在常規治療的基礎上給予雷公籐多苷片。用藥10週後，比較兩組患者治療前後蛋白尿緩解情況以及腎功能、腫瘤壞死因子(TNF-α)、C反應蛋白(CRP)水平變化。結果：觀察組完全緩解5例，有效10例，無變化5例；對照組完全緩解1例，有效3例，無變化16例；觀察組24 h蛋白尿緩解率高于對照組，差異具有統計學意義(P＜0.05)。觀察組24 h尿微量白蛋白、BUN、Scr較治療前顯著降低(P＜0.05)，與對照組治療後比較差異有統計學意義(P＜0.05)。觀察組TNF-α、CRP較治療前顯著降低(P＜0.05)，且顯著低于對照組(P＜0.05)。結論：雷公籐多苷可降低糖尿病腎病患者體內炎性反應，減少24 h尿蛋白，且不良反應較小。
목적：탐토뢰공등다감치료당뇨병신병단백뇨기적료효급치료전후염성인자수평，초보탐토기궤제。방법：2014년1-7월수치당뇨병신병단백뇨기환자40례，안조수자수궤법분위관찰조화대조조각20례。대조조급여상규강혈당약물치료，시험조재상규치료적기출상급여뢰공등다감편。용약10주후，비교량조환자치료전후단백뇨완해정황이급신공능、종류배사인자(TNF-α)、C반응단백(CRP)수평변화。결과：관찰조완전완해5례，유효10례，무변화5례；대조조완전완해1례，유효3례，무변화16례；관찰조24 h단백뇨완해솔고우대조조，차이구유통계학의의(P＜0.05)。관찰조24 h뇨미량백단백、BUN、Scr교치료전현저강저(P＜0.05)，여대조조치료후비교차이유통계학의의(P＜0.05)。관찰조TNF-α、CRP교치료전현저강저(P＜0.05)，차현저저우대조조(P＜0.05)。결론：뢰공등다감가강저당뇨병신병환자체내염성반응，감소24 h뇨단백，차불량반응교소。
Objective:To investigate the efficacy of tripterygium glycosides treated on albuminuria stage of diabetic nephropathy, and its inflammatory factor levels before and after treatment,in order to preliminary study of its mechanism.Methods:40 patients with albuminuria stage of diabetic nephropathy were selected from July 2014 to January 2014.They were randomly divided into the observation group and the control group with 20 cases in each.Patients in the control group were given conventional hypoglycemic drug treatment,while in the observation group were given tripterygium glycosides tablet on the basis of conventional therapy.After treated for 10 weeks,we compared the remission of proteinuria and renal function,tumor necrosis factor(TNF- a),and C reactive protein(CRP) level change in two groups before and after the treatment.Results:In the observation group,there were 5 cases of complete remission,10 cases of effective,and 5 cases had no change;while in the control group,there was 1 cases of complete remission,3 cases of effective,and 16 cases had no change;proteinuria remission rate within 24 h of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The urinary albumin,BUN and Scr in 24 h of the observation group had decreased significantly than before the treatment(P<0.05),and also had statistically significant differences when compared with the control group after treatment(P<0.05).After the treatment,the TNF-alpha and CRP of the observation group had decreased significantly than before the treatment(P<0.05),and also significantly lower than the control group(P<0.05).Conclusion:Tripterygium glycosides can reduce the inflammatory reaction in patients with diabetic nephropathy, and decrease urinary protein within 24 h,and it also has less adverse reactions.
