CAJ | 학술논문

目的：探讨血液透析发生感染患者炎性指标、应激指标检测的临床意义，为临床诊断提供参考依据。方法选取2011年1月－2015年1月40例血液透析发生感染患者为感染组，选择同期40例无感染的血液透析患者为未感染组，检测两组患者降钙素原（PCT）、C‐反应蛋白（CRP）、白细胞介素2（IL‐2）、白细胞介素6（IL‐6）、缺血修饰蛋白（IMA）、肿瘤坏死因子α（TNF‐α）、超氧化物歧化酶（SOD）水平，并对各指标与年龄、感染的关系进行相关性分析；采用SPSS 17．0软件进行统计分析。结果感染组PCT、CRP、IL‐6水平显著高于未感染组，差异有统计学意义（P＜0．01），感染组IL‐2水平低于未感染组，差异有统计学意义（P＜0．01）；感染组 TNF‐α、IMA水平显著高于未感染组，差异有统计学意义（P＜0．01），感染组SOD水平低于未感染组，差异有统计学意义（P＜0．01）；血清PCT、CRP、IL‐6、IMA、TNF‐α的表达之间呈正相关（P＜0．05），血清IL‐2、SOD的表达之间呈正相关（P＜0．05），血清PCT、CRP、IL‐6、IMA、TNF‐α的表达与IL‐2、SOD表达之间呈负相关（P＜0．05）。结论血液透析发生感染患者炎性指标和应激指标可出现异常表达，对上述指标进行检测有利于预测和监测血液透析发生感染的发病及病情。
목적：탐토혈액투석발생감염환자염성지표、응격지표검측적림상의의，위림상진단제공삼고의거。방법선취2011년1월－2015년1월40례혈액투석발생감염환자위감염조，선택동기40례무감염적혈액투석환자위미감염조，검측량조환자강개소원（PCT）、C‐반응단백（CRP）、백세포개소2（IL‐2）、백세포개소6（IL‐6）、결혈수식단백（IMA）、종류배사인자α（TNF‐α）、초양화물기화매（SOD）수평，병대각지표여년령、감염적관계진행상관성분석；채용SPSS 17．0연건진행통계분석。결과감염조PCT、CRP、IL‐6수평현저고우미감염조，차이유통계학의의（P＜0．01），감염조IL‐2수평저우미감염조，차이유통계학의의（P＜0．01）；감염조 TNF‐α、IMA수평현저고우미감염조，차이유통계학의의（P＜0．01），감염조SOD수평저우미감염조，차이유통계학의의（P＜0．01）；혈청PCT、CRP、IL‐6、IMA、TNF‐α적표체지간정정상관（P＜0．05），혈청IL‐2、SOD적표체지간정정상관（P＜0．05），혈청PCT、CRP、IL‐6、IMA、TNF‐α적표체여IL‐2、SOD표체지간정부상관（P＜0．05）。결론혈액투석발생감염환자염성지표화응격지표가출현이상표체，대상술지표진행검측유리우예측화감측혈액투석발생감염적발병급병정。
OBJECTIVE To explore the clinical significance of detection of the inflammatory indicators and stress in‐dicators of the hemodialysis patients with complicated infections so as to provide guidance for clinical diagnosis . METHODS From Jan 2011 to Jan 2015 ,totally 40 hemodialysis patients with complicated infections were chosen as the infection group ,meanwhile ,40 hemodialysis patients without complicated infections were assigned as the non‐infection group .The levels of procalcitonin (PCT) ,C‐reactive protein (CRP) ,interleulin‐2 (IL‐2) ,interleukin‐6 (IL‐6) ,ischemic modified albumin (IMA) ,tumor necrosis factor‐α(TNF‐α) ,and superoxide dismutase(SOD) were determined ,the relationship between the indicators and the age ,and infections was observed ,and the statis‐tical analysis was performed with the use of SPSS 17 .0 software .RESULTS The levels of PCT ,CRP ,and IL‐6 of the infection group were significantly higher than those of the non‐infection group(P<0 .01);the level of IL‐2 of the infection group was significantly lower than that of the non‐infection group ,with statistical significance (P<0 .01);the levels of TNF‐αand IMA of the infection group were significantly higher than those of the non‐infec‐tion group(P<0 .01);the level of SOD of the infection group was significantly lower than that of the non‐infection group(P<0 .01) .The expressions of serum PCT ,CRP ,IL‐6 ,IMA ,and TNF‐αwere positively correlated (P<0 .05) ,the expressions of serum IL‐2 and SOP were positively correlated (P<0 .05) ,while the expressions of ser‐um PCT ,CRP ,IL‐6 ,IMA ,and TNF‐α were negatively correlated with the expressions of IL‐2 and SOD (P<0 .05) .CONCLUSION The hemodialysis patients with complicated infections may appear to the abnormal expres‐sions of the inflammatory indicators and stress indicators ,and the detection of the above indicators is conducive to the prediction and monitoring of onset of infections and illness condition of the hemodialysis patients .