CAJ | 학술논문

目的：分析高龄老年缺血性卒中患者他汀药物的使用并与患者短期预后、不良反应的相关性。方法纳入年龄≥60岁急性缺血性卒中患者425例，按年龄分为高龄组（≥75岁）和老龄组（60～74岁）；记录入院期间及卒中后（90±7）d他汀类药物治疗情况，评估患者短期预后[改良Rankin量表（modified Rankin Scale，mRS）]及相关不良反应情况。对他汀药物使用与短期预后及相关不良反应进行相关性分析。结果入院期间两组他汀药物使用无明显差异；卒中后（90±7）d，高龄组他汀药物使用率较老龄组低（85.0%vs 91.6%，P=0.039），高龄组3个月预后不良率（mRS 3～5分）较老龄组比例高（57.6%vs 30.7%，P＜0.001）。Logistic多因素分析显示，无论高龄组还是老龄组，规律使用他汀类药物是卒中后3个月功能预后的保护性因素[比值比（odds ratio，OR）=0.619，P＜0.05；OR=0.498，P＜0.05]；高龄组规律他汀药物与住院期间孤立性肝酶升高相关（OR=1.789，P＜0.05）。结论高龄卒中患者出院后他汀类药物的依从性及3个月功能预后较老龄患者差；高龄和老龄卒中患者规律使用他汀类药物是短期功能预后的保护性因素；高龄患者规律使用他汀药物与孤立性肝酶升高相关。
목적：분석고령노년결혈성졸중환자타정약물적사용병여환자단기예후、불량반응적상관성。방법납입년령≥60세급성결혈성졸중환자425례，안년령분위고령조（≥75세）화노령조（60～74세）；기록입원기간급졸중후（90±7）d타정류약물치료정황，평고환자단기예후[개량Rankin량표（modified Rankin Scale，mRS）]급상관불량반응정황。대타정약물사용여단기예후급상관불량반응진행상관성분석。결과입원기간량조타정약물사용무명현차이；졸중후（90±7）d，고령조타정약물사용솔교노령조저（85.0%vs 91.6%，P=0.039），고령조3개월예후불량솔（mRS 3～5분）교노령조비례고（57.6%vs 30.7%，P＜0.001）。Logistic다인소분석현시，무론고령조환시노령조，규률사용타정류약물시졸중후3개월공능예후적보호성인소[비치비（odds ratio，OR）=0.619，P＜0.05；OR=0.498，P＜0.05]；고령조규률타정약물여주원기간고립성간매승고상관（OR=1.789，P＜0.05）。결론고령졸중환자출원후타정류약물적의종성급3개월공능예후교노령환자차；고령화노령졸중환자규률사용타정류약물시단기공능예후적보호성인소；고령환자규률사용타정약물여고립성간매승고상관。
Objective To investigate statin utilization in elderly stroke patients and correlation between statin treatment and stroke outcomes of short-term. Methods A total of 425 acute ischemic stroke patients who were older than 60 years old were recruited in this study and divided into two groups by age, the very elderly (75 years old and over) and the elderly (60~74 years old). Collect data of baseline information, statin utilization, blood lipid and liver enzymes levels, short-term functional prognosis assessed by modiifed Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) and statin adverse effects during hospital and follow-up. Logistic regression was used analyzing correlation between statin utilization and short-term stroke prognosis, statin adverse effects in both groups. Results There were no signiifcant differences in statin utilization during hospitalization between two groups. Compared with the elderly group, the very elderly group had a lower statin utilization percent (85.0%vs 91.6%,P=0.039), and a higher rate of poor prognosis (57.6%vs 30.7%,P<0.001) in follow-up. Logistic regression showed that in both groups, regular statin usage showed beneift to short term prognosis (very elderly:odds ratio [OR]=0.619,P<0.05, elderly:OR=0.498,P<0.05); In the very elderly group, regular statin usage was associated with isolated elevation of liver enzymes (OR=1.789, P<0.05). Conclusion The very elderly show poorer statin compliance after discharge and worsenedprognosis in the short term compared with the elderly. Regular statin utilization shows beneift to stroke prognosis in all elderly stroke patients, and is related to isolated elevation of liver enzymes in the very elderly stroke patients.