CAJ | 학술논문

目的：比较乳腺导管内癌伴微浸润（ductal carcinoma in situ with microinvasion ，DCIS‐MI）及导管内癌（ductal carcinoma in situ ，DCIS）的病理和免疫组织化学特征。方法：收集176例DCIS‐MI和184例DCIS患者的临床资料，对其病理和免疫组织化学特征进行分析。结果：两者肿块最大径≥2．5 cm、高级别组织分级、粉刺型组织亚型比例差异均有统计学意义（ P＜0．01）；乳头paget病及腋窝淋巴结转移的患者比例差异无统计学意义（P＞0．05）；免疫组织化学标志物雌激素受体（estrogen receptor ，ER）、孕激素受体（progesterone receptor ，PR）、人表皮生长因子受体（human epidermal growth factor receptor 2， HER2）、Ki‐67、小凹蛋白（caveolin‐1）表达差异均有统计学意义（P＜0．05）。结论：DCIS‐MI在高级别组织分级、粉刺型组织亚型、肿块最大径≥2．5 cm、ER阴性、PR阴性、caveolin‐1阴性、HER2阳性、Ki‐67增殖指数≥14％的发生率高。
목적：비교유선도관내암반미침윤（ductal carcinoma in situ with microinvasion ，DCIS‐MI）급도관내암（ductal carcinoma in situ ，DCIS）적병리화면역조직화학특정。방법：수집176례DCIS‐MI화184례DCIS환자적림상자료，대기병리화면역조직화학특정진행분석。결과：량자종괴최대경≥2．5 cm、고급별조직분급、분자형조직아형비례차이균유통계학의의（ P＜0．01）；유두paget병급액와림파결전이적환자비례차이무통계학의의（P＞0．05）；면역조직화학표지물자격소수체（estrogen receptor ，ER）、잉격소수체（progesterone receptor ，PR）、인표피생장인자수체（human epidermal growth factor receptor 2， HER2）、Ki‐67、소요단백（caveolin‐1）표체차이균유통계학의의（P＜0．05）。결론：DCIS‐MI재고급별조직분급、분자형조직아형、종괴최대경≥2．5 cm、ER음성、PR음성、caveolin‐1음성、HER2양성、Ki‐67증식지수≥14％적발생솔고。
Objective:To compare the clinicopathological and immunohistochemical features of ductal carcinoma in situ(DCIS) with those of DCIS with microinvasion(DCIS‐MI) .Methods:The clinical data of 176 cases of DCIS‐MI and 184 cases of DCIS were collected and the clinicopathological and immunohistochemical features were analyzed .Results:The differences between the proportion of tumor maximal diameter≥2 .5 cm ,high grade ,comedo subtype in DCIS‐MI and those in DCIS ,were statistically significant(P<0 .01) .The differences in proportions of nipple with paget’s disease and axillary lymph node metastasis between the two groups were not statistically significant(P> 0 .05) .The difference between the two groups in immunohistochemical markers estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor 2(HER2),Ki‐67 , caveolin‐1 expression was statistically significant(P<0 .05) .Conclusion:DCIS‐MI shows high incidence in high grade ,comedo subtype ,tumor maximal diameter ≥ 2 .5 cm , ER negative , PR negative , caveolon‐1 positive , HER2‐positive , Ki‐67 proliferation index≥14% .