中华医院感染学杂志
中華醫院感染學雜誌
중화의원감염학잡지
Chinese Journal of Nosocomiology
2015年
10期
2200-2201,2207
,共3页
肿瘤重症%血流感染%病原学
腫瘤重癥%血流感染%病原學
종류중증%혈류감염%병원학
Severe cancer%Bloodstream infection%Etiology
目的：探讨肿瘤重症患者发生血流感染的病原菌分布及其耐药性，为临床合理用药提供参考依据。方法选取2011年6月－2013年6月医院收治的肿瘤重症发生血流感染患者共121例，对感染患者的送检标本进行病原学检测及药敏试验，药敏试验结果初步统计采用WHONET 5．0软件，数据统计采用SPSS19．0软件。结果121例患者共分离出病原菌148株，其中革兰阴性菌75株占50．68％，革兰阳性菌51株占34．46％，真菌22株占14．86％；大肠埃希菌对美罗培南和亚胺培南的敏感率最高，均为100．00％；肺炎克雷伯菌对美罗培南和亚胺培南的敏感率最高，均为100．00％；金黄色葡萄球菌对万古霉素和利奈唑胺的敏感率最高，均为100．00％；而表皮葡萄球菌对大部分抗菌药物耐药率均较高，对利福平、万古霉素、利奈唑胺敏感，敏感率均为100．00％。结论肿瘤重症患者发生血流感染的病原菌以革兰阴性菌为主，临床应根据药敏试验结果合理选择抗菌药物，以减少耐药菌株的产生。
目的：探討腫瘤重癥患者髮生血流感染的病原菌分佈及其耐藥性，為臨床閤理用藥提供參攷依據。方法選取2011年6月－2013年6月醫院收治的腫瘤重癥髮生血流感染患者共121例，對感染患者的送檢標本進行病原學檢測及藥敏試驗，藥敏試驗結果初步統計採用WHONET 5．0軟件，數據統計採用SPSS19．0軟件。結果121例患者共分離齣病原菌148株，其中革蘭陰性菌75株佔50．68％，革蘭暘性菌51株佔34．46％，真菌22株佔14．86％；大腸埃希菌對美囉培南和亞胺培南的敏感率最高，均為100．00％；肺炎剋雷伯菌對美囉培南和亞胺培南的敏感率最高，均為100．00％；金黃色葡萄毬菌對萬古黴素和利奈唑胺的敏感率最高，均為100．00％；而錶皮葡萄毬菌對大部分抗菌藥物耐藥率均較高，對利福平、萬古黴素、利奈唑胺敏感，敏感率均為100．00％。結論腫瘤重癥患者髮生血流感染的病原菌以革蘭陰性菌為主，臨床應根據藥敏試驗結果閤理選擇抗菌藥物，以減少耐藥菌株的產生。
목적：탐토종류중증환자발생혈류감염적병원균분포급기내약성，위림상합리용약제공삼고의거。방법선취2011년6월－2013년6월의원수치적종류중증발생혈류감염환자공121례，대감염환자적송검표본진행병원학검측급약민시험，약민시험결과초보통계채용WHONET 5．0연건，수거통계채용SPSS19．0연건。결과121례환자공분리출병원균148주，기중혁란음성균75주점50．68％，혁란양성균51주점34．46％，진균22주점14．86％；대장애희균대미라배남화아알배남적민감솔최고，균위100．00％；폐염극뢰백균대미라배남화아알배남적민감솔최고，균위100．00％；금황색포도구균대만고매소화리내서알적민감솔최고，균위100．00％；이표피포도구균대대부분항균약물내약솔균교고，대리복평、만고매소、리내서알민감，민감솔균위100．00％。결론종류중증환자발생혈류감염적병원균이혁란음성균위주，림상응근거약민시험결과합리선택항균약물，이감소내약균주적산생。
OBJECTIVE To explore the distribution and drug resistance of the pathogens causing bloodstream infec‐tions in the severe cancer patients so as to provide guidance for reasonable clinical use of antibiotics .METHODS A total of 121 severe cancer patients with complicated bloodstream infections who were treated from Jun 2011 to Jun 2013 were enrolled in the study ,then the etiological detection was conducted for the submitted specimens obtained from the patients with infections ,the drug susceptibility testing was performed ,the preliminary statistical analysis of the results of the drug susceptibility testing was carried out by using WHONET 5 .0 software ,and the data were statistically analyzed wit the use of SPSS19 .0 software .RESULTS Totally 148 strains of pathogens have been isolated from the 121 patients ,including 75 (50 .68% ) strains of gram‐negative bacteria ,51 (34 .46% ) strains of gram‐positive bacteria ,and 22 (14 .86% ) strains of fungi .The drug susceptibility rates of the Escherichia coli strains to meropenem and imipenem were highest (100 .00% );the drug susceptibility rates of the K lebsiella pneu‐moniae strains to meropenem and imipenem were highest (100 .00% );the drug susceptibility rates of the Staphy‐lococcus aureus strains to vancomycin and linezolid were highest (100 .00% );while the Staphylococcus epidermi‐dis strains were highly resistant to most of the antibiotics ,with the drug susceptibility rates to rifampicin ,vanco‐mycin ,and linezolid of 100 .00% .CONCLUSION The gram‐negative bacteria are the predominant pathogens cau‐sing the bloodstream infections in the severe cancer patients ,and it is necessary for the hospital to reasonably use antibiotics based on the results of the drug susceptibility testing so as to reduce the drug‐resistant strains .
