CAJ | 학술논문

目的：分析医院铜绿假单胞菌和鲍氏不动杆菌的多药耐药（MDR）特点，为临床选择合适的抗菌药物及联合用药提供参考。方法收集2011年7月－2012年7月华东医院各临床科室送检的铜绿假单胞菌和鲍氏不动杆菌，采用VITEK‐2 Compact全自动微生物分析系统对分离培养出的细菌进行鉴定和体外药敏分析（MIC），并对其耐药性进行分析。结果收集铜绿假单胞菌和鲍氏不动杆菌共1299株，其中铜绿假单胞菌890株，鲍氏不动杆菌409株；MDR铜绿假单胞菌对碳青霉烯类药物的耐药性严重，仅次于氟喹诺酮类药物，耐左氧氟沙星的铜绿假单胞菌株对亚胺培南也普遍耐药；鲍氏不动杆菌的MDR率要高于铜绿假单胞菌。结论 MDR铜绿假单胞菌和鲍氏不动杆菌引起的感染日益严重，加强医院感染监测，选择合适的治疗药物，对有效控制两菌引起的感染具有重要意义。
목적：분석의원동록가단포균화포씨불동간균적다약내약（MDR）특점，위림상선택합괄적항균약물급연합용약제공삼고。방법수집2011년7월－2012년7월화동의원각림상과실송검적동록가단포균화포씨불동간균，채용VITEK‐2 Compact전자동미생물분석계통대분리배양출적세균진행감정화체외약민분석（MIC），병대기내약성진행분석。결과수집동록가단포균화포씨불동간균공1299주，기중동록가단포균890주，포씨불동간균409주；MDR동록가단포균대탄청매희류약물적내약성엄중，부차우불규낙동류약물，내좌양불사성적동록가단포균주대아알배남야보편내약；포씨불동간균적MDR솔요고우동록가단포균。결론 MDR동록가단포균화포씨불동간균인기적감염일익엄중，가강의원감염감측，선택합괄적치료약물，대유효공제량균인기적감염구유중요의의。
OBJECTIVE To investigate the characteristics of drug resistance of the multidrug‐resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates so as to provide guidance for reasonable clinical use of antibiotics . METHODSFromJul2011toJul2012,theP.aeruginosaandA.baumanniiisolateswerecollectedfromtheclinical departments of Huadong Hospital ,then the isolated bacteria were identified by using VITEK‐2 Compact automatic microorganism analysis system ,the in vitro drug susceptibility testing was performed to observe the drug resist‐ance .RESULTS A total of 1 299 strains of P .aeruginosa and A .baumannii have been collected ,including 890 strains of P .aeruginosa and 409 strains of A .baumannii .The multidrug‐resistant P .aeruginosa was highly resist‐ant to carbapenems ,and the drug resistance rate to fluoroquinolones was higher ;the levofloxacin‐resistant P . aeruginosa was generally resistant to imipenem ;the drug resistance rate of the multidrug‐resistant A .baumannii was higher than that of the multidrug‐resistant P .aeruginosa .CONCLUSION The infections due to the multidrug‐resistant P .aeruginosa and A .baumannii are increasingly serious .It is of great significance to strengthen the sur‐veillance of nosocomial infections and choose appropriate drugs for treatment so as to effectively control the infec‐tions caused by the two species .