CAJ | 학술논문

目的：探讨西洛他唑联合盐酸氨溴索治疗脑梗死老年患者肺炎临床疗效及预后，以降低肺炎并发症。方法选取医院2011年7月－2014年7月脑梗死发生肺部感染患者90例，将患者随机分为对照组和治疗组，每组各45例，对照组在常规治疗基础上给予西洛他唑治疗，治疗组应用西洛他唑联合盐酸氨溴索治疗，治疗两周后进行临床疗效、咳嗽缓解时间、退热时间及住院时间评估，并应用巴氏指数（BI）评估患者生活质量；对比治疗前后白细胞（WBC）计数、C‐反应蛋白（CRP）水平。结果治疗组总有效率为86．67％、对照组为75．56％，两组比较差异有统计学意义（ P＜0．05）；治疗组咳嗽缓解时间、退热时间和住院时间分别为（7．56±1．43） d、（7．18±1．25）d和（26．45±2．08）d ，均低于对照组，两组比较差异有统计学意义（P＜0．05）；治疗组患者BI为61．73±3．51，高于对照组，两组比较差异有统计学意义（ P＜0．05）；治疗组患者 WBC和 CRP分别为（7．18±1．19）×109／L和（8．23±1．30）mg／L ，均低于对照组患者治疗后，两组比较差异有统计学意义（P＜0．05）。结论西洛他唑联合盐酸氨溴索治疗脑梗死老年患者肺炎具有较好的临床疗效，能够缩短治疗时间，改善患者预后。
목적：탐토서락타서연합염산안추색치료뇌경사노년환자폐염림상료효급예후，이강저폐염병발증。방법선취의원2011년7월－2014년7월뇌경사발생폐부감염환자90례，장환자수궤분위대조조화치료조，매조각45례，대조조재상규치료기출상급여서락타서치료，치료조응용서락타서연합염산안추색치료，치료량주후진행림상료효、해수완해시간、퇴열시간급주원시간평고，병응용파씨지수（BI）평고환자생활질량；대비치료전후백세포（WBC）계수、C‐반응단백（CRP）수평。결과치료조총유효솔위86．67％、대조조위75．56％，량조비교차이유통계학의의（ P＜0．05）；치료조해수완해시간、퇴열시간화주원시간분별위（7．56±1．43） d、（7．18±1．25）d화（26．45±2．08）d ，균저우대조조，량조비교차이유통계학의의（P＜0．05）；치료조환자BI위61．73±3．51，고우대조조，량조비교차이유통계학의의（ P＜0．05）；치료조환자 WBC화 CRP분별위（7．18±1．19）×109／L화（8．23±1．30）mg／L ，균저우대조조환자치료후，량조비교차이유통계학의의（P＜0．05）。결론서락타서연합염산안추색치료뇌경사노년환자폐염구유교호적림상료효，능구축단치료시간，개선환자예후。
OBJECTIVE To observe the clinical efficacy of cilostazol combined with ambroxol hydrochloride in treat‐ment of the elderly cerebral infarction patients with pneumonia and analyze the prognosis so as to reduce the inci‐dence of complication of pneumonia .METHODS From Jul 2011 to Jul 2014 ,a total of 90 cerebral infarction pa‐tients with complicated pulmonary infections were enrolled in the study and randomly divided into the control group and the treatment group ,with 45 cases in each;the control group was treated with cilostazol on the basis of the conventional treatment ,while the treatment group was given cilostazol combined with ambroxol hydrochloride . After the treatments for two weeks ,the clinical efficacies ,cough remission time ,fever clearance time ,and length of hospital stay were evaluated ,the quality of life was assessed by using Barthel Index (BI) ,and the white blood cells counts and the level of C‐reactive protein (CRP) were determined and compared before and after the treat‐ments .RESULTS The total effective rate of the treatment group was 86 .67% ,the control group 75 .56% ,and there was significant difference between the two groups (P<0 .05) .The cough remission time of the treatment group was (7 .56 ± 1 .43)days ,shorter than that of the control group;the fever clearance time of the treatment group was (7 .18 ± 1 .25)days ,shorter than that of the control group;the length of hospital stay of the treatment group was (26 .45 ± 2 .08)days ,shorter than that of the control group ,with statistical significance (P<0 .05) . The BI of the treatment group was 61 .73 ± 3 .51 ,significantly higher than that of the control group(P<0 .05) . The WBC counts of the treatment group were (7 .18 ± 1 .19)× 109/L ,lower than those of the control group;the level of CRP of the treatment group was (8 .23 ± 1 .30)mg/L ,lower than that of the control group ,and there were significant differences between the two groups (P< 0 .05) .CONCLUSION Cilostazol combined with ambroxol hydrochloride can achieve significant clinical effect on treatment of the elderly cerebral infarction patients with complicated pneumonia ,shorten the treatment time ,and improve the prognosis .