CAJ | 학술논문

目的：探讨胎盘多肽注射液对四肢骨折术后感染的影响，提高临床诊治水平，降低骨折术后感染的发生。方法选取2010年2月－2014年3月66例四肢骨折术后感染患者为研究对象，随机进行分组，对照组32例，予常规抗菌药物治疗，观察组34例，加用胎盘多肽注射液治疗，对比两组患者治疗后感染控制时间、住院时间、渗液消失时间、皮肤愈合时间及感染C‐反应蛋白（CRP）、白细胞计数（WBC）、白细胞介素‐1（IL‐1）、白细胞介素‐6（IL‐6）、肿瘤坏死因子‐α（TNF‐α）等相关指标水平变化，同时对骨折愈合时间进行比较。结果观察组在感染控制时间、住院时间、渗液消失时间、皮肤愈合时间方面均低于对照组，两组比较差异有统计学意义（P＜0．05）；治疗前两组CRP、IL‐1、IL‐6、TNF‐α、WBC 5项感染指标比较差异无统计学意义；治疗后两组上述感染相关指标均明显低于治疗前水平，治疗前后比较差异均有统计学意义（P＜0．05），观察组治疗后的上述指标均低于对照组，两组比较差异有统计学意义（P＜0．05）；观察组四肢骨折的愈合时间均短于对照组，两组比较差异有统计学意义（P＜0．05）。结论胎盘多肽注射液不仅能降低四肢骨折术后感染率，且能加快骨折愈合时间。
목적：탐토태반다태주사액대사지골절술후감염적영향，제고림상진치수평，강저골절술후감염적발생。방법선취2010년2월－2014년3월66례사지골절술후감염환자위연구대상，수궤진행분조，대조조32례，여상규항균약물치료，관찰조34례，가용태반다태주사액치료，대비량조환자치료후감염공제시간、주원시간、삼액소실시간、피부유합시간급감염C‐반응단백（CRP）、백세포계수（WBC）、백세포개소‐1（IL‐1）、백세포개소‐6（IL‐6）、종류배사인자‐α（TNF‐α）등상관지표수평변화，동시대골절유합시간진행비교。결과관찰조재감염공제시간、주원시간、삼액소실시간、피부유합시간방면균저우대조조，량조비교차이유통계학의의（P＜0．05）；치료전량조CRP、IL‐1、IL‐6、TNF‐α、WBC 5항감염지표비교차이무통계학의의；치료후량조상술감염상관지표균명현저우치료전수평，치료전후비교차이균유통계학의의（P＜0．05），관찰조치료후적상술지표균저우대조조，량조비교차이유통계학의의（P＜0．05）；관찰조사지골절적유합시간균단우대조조，량조비교차이유통계학의의（P＜0．05）。결론태반다태주사액불부능강저사지골절술후감염솔，차능가쾌골절유합시간。
OBJECTIVE To explore the effect of the placental peptide injection on postoperative infections in limb fracture patients so as to improve the clinical diagnosis and treatment and reduce the incidence of the postoperative infections .METHODS From Feb 2010 to Mar 2014 ,a total of 66 limb fracture patients with postoperative infec‐tions were recruited as the study objects and randomly divided into the control group with 32 cases and the obser‐vation group with 34 cases ;the control group was treated with conventional antibiotics ,while the observation group was given additional placental peptide injection .After the treatment ,the time of control of infections ,length of hospital stay ,time of disappearance of exudates ,and skin healing time were compared between the two groups ;the changes of the levels of related indicators for the infections ,including C‐reactive protein (CRP) ,white blood cells (WBC) counts ,interleulin‐1 (IL‐1) ,interleukin‐6 (IL‐6) ,and tumor necrosis factor‐α(TNF‐α) ,were ob‐served ,and the fracture healing time was compared .RESULTS The time of control of infections ,length of hospital stay ,time of disappearance of exudates ,and skin healing time were shorter in the observation group than in the control group ,and there was significant difference between the two groups (P<0 .05) .There was no significant difference in the CRP ,IL‐1 ,IL‐6 ,TNF‐α,or WBC between the two groups before the treatment ;however ,the levels of the above infection‐related indicators of the two groups were significantly lower after the treatment than before the treatment(P<0 .05);after the treatment ,the levels of the above indicators of the observation group were lower than those of the control group ,and there was significant difference (P<0 .05) .The healing time of the limb factures of the observation group was significantly shorter than that of the control group(P< 0 .05) . CONCLUSION The placental peptide injection can not only reduce the incidence of postoperative infections in the limb fractures patients but also facilitate the facture healing .