国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2015年
5期
401-404
,共4页
糖尿病,2型%高脂血症%抗胆固醇血症药%治疗结果%阿托伐他汀%调脂通络饮
糖尿病,2型%高脂血癥%抗膽固醇血癥藥%治療結果%阿託伐他汀%調脂通絡飲
당뇨병,2형%고지혈증%항담고순혈증약%치료결과%아탁벌타정%조지통락음
Diabetes mellitus,type 2%Hyperlipidemias%Anticholesteremic agents%Treatment outcome%Atorvastatin%Tiaozhi-Tongluodecoction
目的：探讨调脂通络饮联合阿托伐他汀片对合并高脂血症的2型糖尿病患者血脂代谢的影响。方法本研究为随机对照研究。将符合纳入标准的患者按随机数字表法分为2组，患者均控制饮食、合理运动，常规口服磺脲类加双胍类药物使血糖控制在正常范围。对照组在此基础上加服阿托伐他汀片，20 mg/d；观察组在对照组治疗基础上加服调脂通络饮，2组均治疗6个月。比较2组治疗前后血糖及血脂水平的变化，并以此为基础评价临床疗效。结果观察组和对照组总有效率分别为87.5%(56/64)和73.0%(46/63)，2组比较差异有统计学意义(χ2＝4.213，P＝0.040)。治疗后，观察组血清总胆固醇[(4.31±1.11)mmol/L比(5.62±1.34)mmol/L，t＝6.004]、三酰甘油[(1.73±0.53)mmol/L比(2.57±1.01)mmol/L， t＝5.855]均较对照组明显降低(P＜0.01)；空腹血糖[(6.31±1.64)mmol/L 比(7.21±1.71)mmol/L，t＝3.027]、餐后2 h血糖[(8.81±1.39)mmol/L比(9.69±1.55)mmol/L，t＝3.370]和糖化血红蛋白[(6.79±1.61)%比(7.96±1.72)%，t＝3.958]较对照组治疗后明显下降(P＜0.01)。结论调脂通络饮联合阿托伐他汀片可有效降低合并高脂血症的2型糖尿病患者血清总胆固醇、三酰甘油，其降血脂效果优于单纯服用阿托伐他汀片。
目的：探討調脂通絡飲聯閤阿託伐他汀片對閤併高脂血癥的2型糖尿病患者血脂代謝的影響。方法本研究為隨機對照研究。將符閤納入標準的患者按隨機數字錶法分為2組，患者均控製飲食、閤理運動，常規口服磺脲類加雙胍類藥物使血糖控製在正常範圍。對照組在此基礎上加服阿託伐他汀片，20 mg/d；觀察組在對照組治療基礎上加服調脂通絡飲，2組均治療6箇月。比較2組治療前後血糖及血脂水平的變化，併以此為基礎評價臨床療效。結果觀察組和對照組總有效率分彆為87.5%(56/64)和73.0%(46/63)，2組比較差異有統計學意義(χ2＝4.213，P＝0.040)。治療後，觀察組血清總膽固醇[(4.31±1.11)mmol/L比(5.62±1.34)mmol/L，t＝6.004]、三酰甘油[(1.73±0.53)mmol/L比(2.57±1.01)mmol/L， t＝5.855]均較對照組明顯降低(P＜0.01)；空腹血糖[(6.31±1.64)mmol/L 比(7.21±1.71)mmol/L，t＝3.027]、餐後2 h血糖[(8.81±1.39)mmol/L比(9.69±1.55)mmol/L，t＝3.370]和糖化血紅蛋白[(6.79±1.61)%比(7.96±1.72)%，t＝3.958]較對照組治療後明顯下降(P＜0.01)。結論調脂通絡飲聯閤阿託伐他汀片可有效降低閤併高脂血癥的2型糖尿病患者血清總膽固醇、三酰甘油，其降血脂效果優于單純服用阿託伐他汀片。
목적：탐토조지통락음연합아탁벌타정편대합병고지혈증적2형당뇨병환자혈지대사적영향。방법본연구위수궤대조연구。장부합납입표준적환자안수궤수자표법분위2조，환자균공제음식、합리운동，상규구복광뇨류가쌍고류약물사혈당공제재정상범위。대조조재차기출상가복아탁벌타정편，20 mg/d；관찰조재대조조치료기출상가복조지통락음，2조균치료6개월。비교2조치료전후혈당급혈지수평적변화，병이차위기출평개림상료효。결과관찰조화대조조총유효솔분별위87.5%(56/64)화73.0%(46/63)，2조비교차이유통계학의의(χ2＝4.213，P＝0.040)。치료후，관찰조혈청총담고순[(4.31±1.11)mmol/L비(5.62±1.34)mmol/L，t＝6.004]、삼선감유[(1.73±0.53)mmol/L비(2.57±1.01)mmol/L， t＝5.855]균교대조조명현강저(P＜0.01)；공복혈당[(6.31±1.64)mmol/L 비(7.21±1.71)mmol/L，t＝3.027]、찬후2 h혈당[(8.81±1.39)mmol/L비(9.69±1.55)mmol/L，t＝3.370]화당화혈홍단백[(6.79±1.61)%비(7.96±1.72)%，t＝3.958]교대조조치료후명현하강(P＜0.01)。결론조지통락음연합아탁벌타정편가유효강저합병고지혈증적2형당뇨병환자혈청총담고순、삼선감유，기강혈지효과우우단순복용아탁벌타정편。
Objective To observe the effects ofTiaozhi-Tongluo decoction combined with atorvastatin tablets on type 2 diabetes mellitus and lipid metabolism in patients with hyperlipidemia.Methods All patients were recruited into a control group and an observation group. Patients in both groups were performed diet control, reasonable exercise, and routine oral sulfonylureas and biguanides to make glucose level in a normal range. The control group was treated with atorvastatin tablets, 20 mg/d. While the observation group was treated with atorvastatin tablets plusTiaozhi-Tongluo decoction. After both groups were treated for 6 months, the blood glucose and blood lipid level were detected for the evaluation of clinical curative effect.Results The total effective rates in the observation group and the control group were 87.5%(56/64)and 73.0%(46/63), respectively, the difference was statistically significant (χ2=4.213,P=0.040). The serum levels of total cholesterol (4.31 ± 1.11 mmol/Lvs.5.62 ± 1.34 mmol/L,t=6.004) and triglyceride (1.73 ± 0.53 mmol/Lvs. 2.57 ± 1.01 mmol/L,t=5.855) in the observation group were significant lower than those in the control group. The levels of fasting plasma glucose (6.31 ± 1.64 mmol/Lvs.7.21 ± 1.71 mmol/L,t=3.027) , 2-h postchallenge plasma glucose (8.81 ± 1.39 mmol/Lvs.9.69 ± 1.55 mmol/L,t=3.370), and glycosylated hemoglobin (6.79% ± 1.61%vs.7.96% ± 1.72%,t=3.958) in the observation group after treatment were significantly decreased than the control group (P<0.01).ConclusionTiaozhi-Tongluodecoction combined with atorvastatin can reduce serum total cholesterol and triacylglycerol, and it is superior to atorvastatin alone in reducing lipidemia in type 2 diabetes mellitus patients with hyperlipidemia.
