中国临床医学
中國臨床醫學
중국림상의학
CLINICAL MEDICAL JOURNAL OF CHINA
2015年
2期
126-129
,共4页
宫颈癌%TNFAIP8基因家族%多态性%预后
宮頸癌%TNFAIP8基因傢族%多態性%預後
궁경암%TNFAIP8기인가족%다태성%예후
Cervical cancer%TNFAIP8 gene family%Polymorphism%Prognosis
目的：探讨肿瘤坏死因子α诱导蛋白8（tumor necrosis factor‐α‐induced protein 8，TNFAIP8）家族基因的单核苷酸多态性（single nucleotide polymorphism ，SNP）位点在宫颈癌预后评估中的作用。方法：选择2008—2009年行根治性子宫切除术并获得至少2年随访的144例宫颈癌患者。采用 Taqman探针检测患者 TNFAIP8家族基因中3个多态性位点（TNFAIP8‐rs11064、TNFAIP8‐rs3813308和TNFAIP8L1‐rs1060555）的基因分型。分析 TNFAIP8家族基因SNP位点与宫颈癌预后的关系。结果：携带TNFAIP8L1‐rs1060555 GG的宫颈癌患者相较于携带CG／CC基因型者，肿瘤复发的危险度显著增加（校正HR＝3．25，95％ CI：1．06～9．95）。联合效应分析发现，携带TNFAIP8基因家族2～3个危险基因型的患者相较于携带0～1个危险基因型者，肿瘤复发的危险度显著增加（校正 HR＝2．55，95％ CI：1．02～6．36）。结论：TNFAIP8家族基因的SNP位点有望为宫颈癌的预后评估提供参考。
目的：探討腫瘤壞死因子α誘導蛋白8（tumor necrosis factor‐α‐induced protein 8，TNFAIP8）傢族基因的單覈苷痠多態性（single nucleotide polymorphism ，SNP）位點在宮頸癌預後評估中的作用。方法：選擇2008—2009年行根治性子宮切除術併穫得至少2年隨訪的144例宮頸癌患者。採用 Taqman探針檢測患者 TNFAIP8傢族基因中3箇多態性位點（TNFAIP8‐rs11064、TNFAIP8‐rs3813308和TNFAIP8L1‐rs1060555）的基因分型。分析 TNFAIP8傢族基因SNP位點與宮頸癌預後的關繫。結果：攜帶TNFAIP8L1‐rs1060555 GG的宮頸癌患者相較于攜帶CG／CC基因型者，腫瘤複髮的危險度顯著增加（校正HR＝3．25，95％ CI：1．06～9．95）。聯閤效應分析髮現，攜帶TNFAIP8基因傢族2～3箇危險基因型的患者相較于攜帶0～1箇危險基因型者，腫瘤複髮的危險度顯著增加（校正 HR＝2．55，95％ CI：1．02～6．36）。結論：TNFAIP8傢族基因的SNP位點有望為宮頸癌的預後評估提供參攷。
목적：탐토종류배사인자α유도단백8（tumor necrosis factor‐α‐induced protein 8，TNFAIP8）가족기인적단핵감산다태성（single nucleotide polymorphism ，SNP）위점재궁경암예후평고중적작용。방법：선택2008—2009년행근치성자궁절제술병획득지소2년수방적144례궁경암환자。채용 Taqman탐침검측환자 TNFAIP8가족기인중3개다태성위점（TNFAIP8‐rs11064、TNFAIP8‐rs3813308화TNFAIP8L1‐rs1060555）적기인분형。분석 TNFAIP8가족기인SNP위점여궁경암예후적관계。결과：휴대TNFAIP8L1‐rs1060555 GG적궁경암환자상교우휴대CG／CC기인형자，종류복발적위험도현저증가（교정HR＝3．25，95％ CI：1．06～9．95）。연합효응분석발현，휴대TNFAIP8기인가족2～3개위험기인형적환자상교우휴대0～1개위험기인형자，종류복발적위험도현저증가（교정 HR＝2．55，95％ CI：1．02～6．36）。결론：TNFAIP8가족기인적SNP위점유망위궁경암적예후평고제공삼고。
Objective:To investigate the predictive value of polymorphisms in the tumor necrosis factor‐α‐induced protein 8 (TNFalP8) gene family in the prognosis of cervical cancer .Methods:A total of 144 cervical cancer patients who had been followed up for at least two years were recruited . Three polymorphism sites TNFalP8‐rs11064 , TNFalP8‐rs3813308 and TNFalP8L1‐rs1060555 in the TNFalP8 gene family were genotyped by the Taqman assay .The associations of polymorphisms in the TNFalP8 gene family with prognosis of cervical cancer were analyzed . Results:Compared with CG/CC genotypes ,tumor recurrence in TNFalP8L1‐rs1060555 GG genotype carriers increased (adjusted HR=3 .25 ,95% CI:1 .06‐9 .95) .Combined analysis for the three polymorphisms indicated that compared with 0‐1 risk genotype carriers ,tumor recurrence in 2‐3 risk genotype carriers increased (adjusted HR = 2 .55 ,95% CI:1 .02‐6 .36) . Conclusions:Polymorphisms in TNFalP8 gene family may be predictive biomarkers for prognosis of cervical cancer .
