中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
15期
2315-2319
,共5页
组织构建%软骨组织工程%微骨折%骨软骨移植%关节软骨缺损治疗%实施效果
組織構建%軟骨組織工程%微骨摺%骨軟骨移植%關節軟骨缺損治療%實施效果
조직구건%연골조직공정%미골절%골연골이식%관절연골결손치료%실시효과
Subject headings:Fractures,Bone%Cartilage%Bone Transplantation
背景：文献介绍微骨折与骨软骨移植治疗关节软骨缺损都有效，均为目前临床治疗手段。<br> 目的：比较微骨折与骨软骨移植在关节软骨缺损治疗中的实施效果。<br> 方法：回顾性分析50例(50个膝关节)关节软骨缺损患者的临床资料。按照外科修复方式分为2组，每组25例。骨软骨移植组患者采用自体骨软骨移植修复膝关节软骨缺损；微骨折组患者运用微骨折方法修复膝关节软骨缺损。两组患者均随访超过24个月，比较两组患者的膝关节美国特种外科医院(Hospital for Special Surgery，HSS)评分及临床疗效，观察两组患者不良反应和并发症。<br> 结果与结论：骨软骨移植组患者的膝关节HSS评分>85分和60-85分患者数量明显多于微骨折组(P <0.05)，骨软骨移植组总有效率显著高于微骨折组(92%，60.0%，P <0.05)。两组患者均无并发症发生。结果表明骨软骨移植在关节软骨缺损治疗中较微骨折具有较好的实施效果。
揹景：文獻介紹微骨摺與骨軟骨移植治療關節軟骨缺損都有效，均為目前臨床治療手段。<br> 目的：比較微骨摺與骨軟骨移植在關節軟骨缺損治療中的實施效果。<br> 方法：迴顧性分析50例(50箇膝關節)關節軟骨缺損患者的臨床資料。按照外科脩複方式分為2組，每組25例。骨軟骨移植組患者採用自體骨軟骨移植脩複膝關節軟骨缺損；微骨摺組患者運用微骨摺方法脩複膝關節軟骨缺損。兩組患者均隨訪超過24箇月，比較兩組患者的膝關節美國特種外科醫院(Hospital for Special Surgery，HSS)評分及臨床療效，觀察兩組患者不良反應和併髮癥。<br> 結果與結論：骨軟骨移植組患者的膝關節HSS評分>85分和60-85分患者數量明顯多于微骨摺組(P <0.05)，骨軟骨移植組總有效率顯著高于微骨摺組(92%，60.0%，P <0.05)。兩組患者均無併髮癥髮生。結果錶明骨軟骨移植在關節軟骨缺損治療中較微骨摺具有較好的實施效果。
배경：문헌개소미골절여골연골이식치료관절연골결손도유효，균위목전림상치료수단。<br> 목적：비교미골절여골연골이식재관절연골결손치료중적실시효과。<br> 방법：회고성분석50례(50개슬관절)관절연골결손환자적림상자료。안조외과수복방식분위2조，매조25례。골연골이식조환자채용자체골연골이식수복슬관절연골결손；미골절조환자운용미골절방법수복슬관절연골결손。량조환자균수방초과24개월，비교량조환자적슬관절미국특충외과의원(Hospital for Special Surgery，HSS)평분급림상료효，관찰량조환자불량반응화병발증。<br> 결과여결론：골연골이식조환자적슬관절HSS평분>85분화60-85분환자수량명현다우미골절조(P <0.05)，골연골이식조총유효솔현저고우미골절조(92%，60.0%，P <0.05)。량조환자균무병발증발생。결과표명골연골이식재관절연골결손치료중교미골절구유교호적실시효과。
BACKGROUND:Both microfracture and osteochondral transplantation are effective tools in the clinical treatment of articular cartilage defects. <br> OBJECTIVE: To observe the implementation results of microfracture and osteochondral transplantation in the treatment of articular cartilage defects. <br> METHODS:The clinical data of 50 cases (50 knees) of articular cartilage defects were retrospectively analyzed. There were two groups according to surgical repair methods: autogenous osteochondral transplantation+ microfracture in observation group (n=25), and microfracture in control group (n=25). Patients in the two groups were folowed up for over 24 hours to compare the Hospital for Special Surgery scores, clinical efficacy, adverse effects and complications. <br> RESULTS AND CONCLUSION:The number of patients whose Hospital for Special Surgery score was > 85 points and 60 to 85 points in the observation group was significantly larger than that in the control group (P< 0.05), and the total treatment effective rate of patients in the observation group was significantly higher than that of the control group (92%vs. 60%,P < 0.05). No complications occurred in both two groups. These findings indicate that osteochondral transplantation has better implementation results in the treatment of articular cartilage defects than microfracture.
