CAJ | 학술논문

Ikaros 是造血细胞分化和免疫系统发育的重要调节因子，并且作为肿瘤抑制因子，Ikaros异常会阻滞 T、B 细胞的发育或导致肿瘤形成。在白血病患者中，Ikaros 发生突变导致患者治疗反应下降及长期生存率降低。Ikaros 在白血病发生和预后中的机制研究已成为人们关注的热点。
Ikaros 시조혈세포분화화면역계통발육적중요조절인자，병차작위종류억제인자，Ikaros이상회조체 T、B 세포적발육혹도치종류형성。재백혈병환자중，Ikaros 발생돌변도치환자치료반응하강급장기생존솔강저。Ikaros 재백혈병발생화예후중적궤제연구이성위인문관주적열점。
Ikaros is a regulatory factor playing an important role in control of the development of hema-topoietic cells and immune system;and as a tumor suppressor,its aberration can cause both T and B lineage development arrest and neoplastic transformation,leading to insensitive to therapy and poor prognosis in actue lymphoblastic leukemia. Recently,researches on how Ikaros affects the leukemogenesis and prognosis become the focus of attention.