蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2015年
4期
450-452,455
,共4页
肝肿瘤%基质金属蛋白酶-9%微血管密度%微血管生成
肝腫瘤%基質金屬蛋白酶-9%微血管密度%微血管生成
간종류%기질금속단백매-9%미혈관밀도%미혈관생성
liver neoplasm%matrix metalloproteinases-9%microvessel density%angiogenesis
目的：：探讨细胞外基质金属蛋白酶诱导因子( CD147)和基质金属蛋白酶-9( MMP-9)在肝细胞肝癌组织中的表达与肝细胞肝癌血管生成的关系。方法：采用免疫组织化学法检测63例肝细胞肝癌组织中CD147和MMP-9的表达,光镜下计数(分化抗原105 CD105)标记的微血管密度。结果：63例肝细胞肝癌组织中CD147阳性率为65.1%,MMP-9阳性率73.0%,二者阳性率在肿瘤大小、门静脉癌栓、肿瘤分化和TNM分期间差异均有统计学意义(P<0.05~P<0.01),而在患者的性别、年龄及甲胎蛋白的表达水平间差异无统计学意义(P>0.05)。 CD147和MMP-9阳性组微血管密度值均明显高于阴性组(P<0.01)。 CD147在肝细胞肝癌中的表达与MMP-9表达呈正相关关系(P<0.01)。结论：肝细胞肝癌组织中CD147表达上调可能通过促进MMP-9的生成参与肝癌微血管的生成,进而有利于肝癌侵袭和转移。
目的：：探討細胞外基質金屬蛋白酶誘導因子( CD147)和基質金屬蛋白酶-9( MMP-9)在肝細胞肝癌組織中的錶達與肝細胞肝癌血管生成的關繫。方法：採用免疫組織化學法檢測63例肝細胞肝癌組織中CD147和MMP-9的錶達,光鏡下計數(分化抗原105 CD105)標記的微血管密度。結果：63例肝細胞肝癌組織中CD147暘性率為65.1%,MMP-9暘性率73.0%,二者暘性率在腫瘤大小、門靜脈癌栓、腫瘤分化和TNM分期間差異均有統計學意義(P<0.05~P<0.01),而在患者的性彆、年齡及甲胎蛋白的錶達水平間差異無統計學意義(P>0.05)。 CD147和MMP-9暘性組微血管密度值均明顯高于陰性組(P<0.01)。 CD147在肝細胞肝癌中的錶達與MMP-9錶達呈正相關關繫(P<0.01)。結論：肝細胞肝癌組織中CD147錶達上調可能通過促進MMP-9的生成參與肝癌微血管的生成,進而有利于肝癌侵襲和轉移。
목적：：탐토세포외기질금속단백매유도인자( CD147)화기질금속단백매-9( MMP-9)재간세포간암조직중적표체여간세포간암혈관생성적관계。방법：채용면역조직화학법검측63례간세포간암조직중CD147화MMP-9적표체,광경하계수(분화항원105 CD105)표기적미혈관밀도。결과：63례간세포간암조직중CD147양성솔위65.1%,MMP-9양성솔73.0%,이자양성솔재종류대소、문정맥암전、종류분화화TNM분기간차이균유통계학의의(P<0.05~P<0.01),이재환자적성별、년령급갑태단백적표체수평간차이무통계학의의(P>0.05)。 CD147화MMP-9양성조미혈관밀도치균명현고우음성조(P<0.01)。 CD147재간세포간암중적표체여MMP-9표체정정상관관계(P<0.01)。결론：간세포간암조직중CD147표체상조가능통과촉진MMP-9적생성삼여간암미혈관적생성,진이유리우간암침습화전이。
Objective:To explore the expressions of CD147 and matrix metalloproteinases-9 in hepatocellular carcinoma, and its correlation with angiogenesis. Methods:The expressions of CD147 and MMP-9 in hepatocellular carcinoma tissues of 63 cases were detected using immunohistochemistry SP method. The microvessel density labeled by differentiation antigen 105(CD105) was recorded under optical microscope. Results:The positive expression rates of CD147 and MMP-9 in hepatocellular carcinoma tissues of 63 cases were 65. 1% and 73. 0%,respectively. The differences of positive expression rates of CD147 and MMP-9 in tumor size,portal vein cancer embolism,tumor differentiation and TNM stage were statistically significant(P<0. 05 to P <0. 01),but their differences in gender,age and serum level ofα-fetal protein were not statistically significant(P>0. 05). The level of microvessel density in case with positive CD147 and MMP-9 expressions was significantly higher than that in case with negative CD147 and MMP-9 expressions ( P<0.01). The expressions of CD147 and MMP-9 were significantly positive correlation in hepatocellular carcinoma(P < 0. 01). Conclusions:Upregulation of the CD147 expression in hepatocellular carcinoma can promote angiogenesis through increasing the production of MMP-9,which can lead to tumor invasion and metastasis.
