蚌埠医学院学报
蚌埠醫學院學報
방부의학원학보
ACTA ACADEMIAE MEDICINAE BENGBU
2015年
4期
447-449
,共3页
结直肠肿瘤%肝转移%γ-神经突触核蛋白
結直腸腫瘤%肝轉移%γ-神經突觸覈蛋白
결직장종류%간전이%γ-신경돌촉핵단백
colorectal neoplasms%liver metastasis%gamma-synuclein
目的：：探讨结直肠癌( CRC)肝转移患者γ-神经突触核蛋白( SNCG)高表达的临床意义。方法：根据术后癌细胞转移情况将219例患者分为肝转移组114例和无肝转移组105例。采用免疫组织化学法,分析SNCG表达水平与CRC患者术后肝转移的关系及其与术后无病生存时间和总生存时间的关系。结果：SNCG阳性率在肝转移组为71.96%,无肝转移组为28.04%。Logistic多因素分析显示,SNCG表达是判断CRC术后是否有肝转移的独立因素(P<0.01)。 SNCG阳性表达与阴性表达的肝转移患者术后无病生存时间分别为(48.70±5.40)个月和(78.75±4.23)个月,总生存时间分别为(51.10±5.20)个月和(80.29±4.12)个月,SNCG阴性患者的生存时间均明显长于SNCG阳性患者(P<0.01)。结论：SNCG表达水平越高,CRC患者术后肝转移的风险越高,无病生存期越短。 CRC组织中SNCG高表达可以作为预测肝转移的指标,值得临床推广。
目的：：探討結直腸癌( CRC)肝轉移患者γ-神經突觸覈蛋白( SNCG)高錶達的臨床意義。方法：根據術後癌細胞轉移情況將219例患者分為肝轉移組114例和無肝轉移組105例。採用免疫組織化學法,分析SNCG錶達水平與CRC患者術後肝轉移的關繫及其與術後無病生存時間和總生存時間的關繫。結果：SNCG暘性率在肝轉移組為71.96%,無肝轉移組為28.04%。Logistic多因素分析顯示,SNCG錶達是判斷CRC術後是否有肝轉移的獨立因素(P<0.01)。 SNCG暘性錶達與陰性錶達的肝轉移患者術後無病生存時間分彆為(48.70±5.40)箇月和(78.75±4.23)箇月,總生存時間分彆為(51.10±5.20)箇月和(80.29±4.12)箇月,SNCG陰性患者的生存時間均明顯長于SNCG暘性患者(P<0.01)。結論：SNCG錶達水平越高,CRC患者術後肝轉移的風險越高,無病生存期越短。 CRC組織中SNCG高錶達可以作為預測肝轉移的指標,值得臨床推廣。
목적：：탐토결직장암( CRC)간전이환자γ-신경돌촉핵단백( SNCG)고표체적림상의의。방법：근거술후암세포전이정황장219례환자분위간전이조114례화무간전이조105례。채용면역조직화학법,분석SNCG표체수평여CRC환자술후간전이적관계급기여술후무병생존시간화총생존시간적관계。결과：SNCG양성솔재간전이조위71.96%,무간전이조위28.04%。Logistic다인소분석현시,SNCG표체시판단CRC술후시부유간전이적독립인소(P<0.01)。 SNCG양성표체여음성표체적간전이환자술후무병생존시간분별위(48.70±5.40)개월화(78.75±4.23)개월,총생존시간분별위(51.10±5.20)개월화(80.29±4.12)개월,SNCG음성환자적생존시간균명현장우SNCG양성환자(P<0.01)。결론：SNCG표체수평월고,CRC환자술후간전이적풍험월고,무병생존기월단。 CRC조직중SNCG고표체가이작위예측간전이적지표,치득림상추엄。
Objective:To investigate the clinical significance of high expression of synuclein gamma(SNCG) in colorectal cancer ( CRC) patients with liver metastases. Methods:Two hundred and nineteen patients with CRC were divided into the liver metastasis group ( 114 cases ) and non-liver metastasis group ( 105 cases ) . The relationships between the SNCG level identified by immunohistochemistry and liver metastasis, disease-free survival time after surgery and overall survival were analyzed. Results:The positive rates of SNCG in liver metastasis group and non-liver metastasis group were 71. 96% and 28. 04%,respectively. Multivariate analysis showed that the expression of SNCG in CRC patients was an independent factor of hepatic metastasis(P<0. 01). The disease-free survival time after surgery and overall survival in liver metastasis patients with the positive and negative SNCG expressions were (48. 70 ± 5. 40) &(78. 75 ± 4. 23) months and(51. 10 ± 5. 20) &(80. 29 ± 4. 12) months,respectively. The survival time in negative SNCG patient was higher than that in positive SNCG patient(P<0. 01). Conclusions:With the increasing of SNCG expression,the liver metastasis and disease-free survival time in CRC patients increase and shorten, respectively. High expression of SNCG in CRC tissue can be used as a prediction index of liver metastasis.
