CAJ | 학술논문

背景 Parthanatos是新近发现的一种与人类多种疾病有关,通过激活多聚腺苷二磷酸(ADP)核糖聚合酶-1[poly(ADP-ribose)polymerase-1,PARP-1]引发,不同于坏死、凋亡和自噬的新的细胞死亡形式.目前发现N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)预处理可诱导产生一种内源性存活蛋白Iduna,通过与多聚ADP核糖聚合物(poly ADP-ribose,PAR)结合,有效干预兴奋毒性引起的神经细胞parthanatos死亡.目的了解内源性保护蛋白Iduna在抑制大脑神经元parthanatos中的作用.内容就细胞发生parthanatos的可能机制,以及内源性抑制蛋白Iduna如何作用于PARP-1通路产生脑保护作用最新研究进展作一综述.趋向随着对Iduna研究的不断深入,临床治疗parthanatos相关疾病的方法也会不断涌现.
배경 Parthanatos시신근발현적일충여인류다충질병유관,통과격활다취선감이린산(ADP)핵당취합매-1[poly(ADP-ribose)polymerase-1,PARP-1]인발,불동우배사、조망화자서적신적세포사망형식.목전발현N-갑기-D-천동안산(N-methyl-D-aspartate,NMDA)예처리가유도산생일충내원성존활단백Iduna,통과여다취ADP핵당취합물(poly ADP-ribose,PAR)결합,유효간예흥강독성인기적신경세포parthanatos사망.목적 료해내원성보호단백Iduna재억제대뇌신경원parthanatos중적작용.내용 취세포발생parthanatos적가능궤제,이급내원성억제단백Iduna여하작용우PARP-1통로산생뇌보호작용최신연구진전작일종술.추향 수착대Iduna연구적불단심입,림상치료parthanatos상관질병적방법야회불단용현.
Background Parthanatos is recently discovered as a new form of cell death,which is poly (ADP-ribose) polymerase-1 (PARP-1) dependent,related to a number of diseases,different from necrosis,apoptosis,and autophagy.Recently,new studies find that N-methyl-D-aspartate(NMDA) preconditioning can induce a cell survival protein Iduna,which is an endogenous inhibitor to block parthanatos through binding with poly ADP-ribose (PAR) polymer,to against excitotoxicity.Objective Summarizing the role of possible pathogenesis of parthanatos,and how iduna as an endogenous inhibitor protect brain by interfering with PARP-1 pathway.Content Review the effect of Iduna as an endogenous inhibitor on brain protection through PARP1 pathway and the possible mechanism of parthanatos in brain neurons in recent studies.Trend With advanced research on Iduna,approaches of clinical therapy on parthanatos-related diseases will be revealed.