CAJ | 학술논문

目的：探讨慢性荨麻疹和慢性湿疹患者食物特异性IgG变应原和血清总IgE的水平,为临床诊治提供参考。方法：应用ELISA法,检测153例慢性荨麻疹患者与135例慢性湿疹患者血清总IgE与14种食物特异性IgG,并与48名健康体检者对照。结果：慢性荨麻疹食物特异性IgG阳性率94.1%,慢性湿疹阳性率95.6%,而健康体检人群阳性率54.2%。以鸡蛋(蛋白/蛋黄)、牛奶、鳕鱼、螃蟹、大豆阳性率最高,鸡肉、玉米、大米、虾、西红柿、小麦次之,猪肉、牛肉、蘑菇较低。慢性荨麻疹和慢性湿疹患者血清总IgE均为100.0%阳性,而健康体检人群仅有29.8%。结论：慢性荨麻疹、慢性湿疹不仅与IgE介导的Ⅰ型变态反应有关,还与食物特异性IgG引起的不耐受有一定相关性；其检测可及时调整患者食谱,缓解临床症状,为患者诊治提供有益帮助。
목적：탐토만성담마진화만성습진환자식물특이성IgG변응원화혈청총IgE적수평,위림상진치제공삼고。방법：응용ELISA법,검측153례만성담마진환자여135례만성습진환자혈청총IgE여14충식물특이성IgG,병여48명건강체검자대조。결과：만성담마진식물특이성IgG양성솔94.1%,만성습진양성솔95.6%,이건강체검인군양성솔54.2%。이계단(단백/단황)、우내、설어、방해、대두양성솔최고,계육、옥미、대미、하、서홍시、소맥차지,저육、우육、마고교저。만성담마진화만성습진환자혈청총IgE균위100.0%양성,이건강체검인군부유29.8%。결론：만성담마진、만성습진불부여IgE개도적Ⅰ형변태반응유관,환여식물특이성IgG인기적불내수유일정상관성；기검측가급시조정환자식보,완해림상증상,위환자진치제공유익방조。
Objective:To explore the levels of serum total IgE and food allergen-specific IgG antibody in patients with chronic urticaria and eczema,and provide the reference for their clinical diagnosis and therapy. Methods:The levels of the serum total IgE in 153 patients with chronic urticaria and 135 patients with chronic eczema, and allergen-specific IgG antibodies in 14 kinds of food were measured by enzyme linked immunosorbent assay( ELISA) . Forty-eight healthy people were set as the control. Results:The total positive rates of specific IgG antibodies in chronic urticaria,chronic eczema and healthy people were 94. 1%,95. 6% and 54. 2%,respectively. The most common food allergen were egg,milk,cod,crab and bean,followed by chicken,maize,rice,shrimp,tomato and wheat,and then pork,beef and mushrooms. The total positive rates of total serum IgE in chronic urticaria and eczema patients were 100. 0%,but it was 29. 8% in healthy people. Conclusions:The chronic urticaria and eczema are not only associated with typeⅠallergy,but also with food intolerance induced by the food allergen-specific IgG. The detection of IgE and IgG levels can help adjust the recipes and alleviate the clinical symptoms.