中华地方病学杂志
中華地方病學雜誌
중화지방병학잡지
Chinese Journal of Endemiology
2015年
4期
247-249
,共3页
杨晓艳%辛有全%魏柏青%熊浩明%祁美英%靳娟%赵海红%赵小龙%李翔
楊曉豔%辛有全%魏柏青%熊浩明%祁美英%靳娟%趙海紅%趙小龍%李翔
양효염%신유전%위백청%웅호명%기미영%근연%조해홍%조소룡%리상
鼠疫%病原学%流行病学
鼠疫%病原學%流行病學
서역%병원학%류행병학
Plague%Etiology%Epidemiology
目的 探讨西藏藏南地区新增疫源县鼠疫菌株生物学特点及流行病学意义,为鼠疫防治提供科学依据.方法 对1999-2008年藏南地区新增疫源县分离的28株鼠疫菌株进行生化试验、毒力测定、毒力因子鉴定、质粒分析、差异区段(DFR)分型等研究.结果 生态型为青藏高原型、岗底斯山型的鼠疫菌分别有11、17株;基因组型为5、19型的鼠疫菌分别有2、26株.存在6×106、45×106、65×106和6×106、36×106、45×106、65×106两种质粒谱,其中6×106、36×106、45×106、65×106质粒组成是该地区新发现的质粒谱.28株鼠疫菌均能产生鼠疫菌荚膜抗原(F1),鼠疫杆菌素Ⅰ(Pst Ⅰ)阳性的菌株占96.4%(27/28),毒力抗原因子(VW)阳性的菌株占32.1%(9/28),色素沉着因子(pgm)阳性的菌株占46.4%(13/28);从28株鼠疫菌中选取具有代表性的11株进行毒力测定,81.8%(9/11)的鼠疫菌为强毒菌.结论 1999-2008年西藏藏南地区新增疫源县鼠疫菌具备青藏高原鼠疫病原体特性,鼠疫菌的毒力强,因此,应加大鼠疫监测力度,严防动物鼠疫波及人间.
目的 探討西藏藏南地區新增疫源縣鼠疫菌株生物學特點及流行病學意義,為鼠疫防治提供科學依據.方法 對1999-2008年藏南地區新增疫源縣分離的28株鼠疫菌株進行生化試驗、毒力測定、毒力因子鑒定、質粒分析、差異區段(DFR)分型等研究.結果 生態型為青藏高原型、崗底斯山型的鼠疫菌分彆有11、17株;基因組型為5、19型的鼠疫菌分彆有2、26株.存在6×106、45×106、65×106和6×106、36×106、45×106、65×106兩種質粒譜,其中6×106、36×106、45×106、65×106質粒組成是該地區新髮現的質粒譜.28株鼠疫菌均能產生鼠疫菌莢膜抗原(F1),鼠疫桿菌素Ⅰ(Pst Ⅰ)暘性的菌株佔96.4%(27/28),毒力抗原因子(VW)暘性的菌株佔32.1%(9/28),色素沉著因子(pgm)暘性的菌株佔46.4%(13/28);從28株鼠疫菌中選取具有代錶性的11株進行毒力測定,81.8%(9/11)的鼠疫菌為彊毒菌.結論 1999-2008年西藏藏南地區新增疫源縣鼠疫菌具備青藏高原鼠疫病原體特性,鼠疫菌的毒力彊,因此,應加大鼠疫鑑測力度,嚴防動物鼠疫波及人間.
목적 탐토서장장남지구신증역원현서역균주생물학특점급류행병학의의,위서역방치제공과학의거.방법 대1999-2008년장남지구신증역원현분리적28주서역균주진행생화시험、독력측정、독력인자감정、질립분석、차이구단(DFR)분형등연구.결과 생태형위청장고원형、강저사산형적서역균분별유11、17주;기인조형위5、19형적서역균분별유2、26주.존재6×106、45×106、65×106화6×106、36×106、45×106、65×106량충질립보,기중6×106、36×106、45×106、65×106질립조성시해지구신발현적질립보.28주서역균균능산생서역균협막항원(F1),서역간균소Ⅰ(Pst Ⅰ)양성적균주점96.4%(27/28),독력항원인자(VW)양성적균주점32.1%(9/28),색소침착인자(pgm)양성적균주점46.4%(13/28);종28주서역균중선취구유대표성적11주진행독력측정,81.8%(9/11)적서역균위강독균.결론 1999-2008년서장장남지구신증역원현서역균구비청장고원서역병원체특성,서역균적독력강,인차,응가대서역감측력도,엄방동물서역파급인간.
Objective To investigate the biological characteristics and epidemiological significance of Yersinia pestis in the new foci of plague in the south of Tibet,in order to provide a scientific basis for plague prevention and control.Methods Totally 28 strains were separated in the new foci of plague in the south of Tibet from 1999 to 2008 to do biochemical test,toxicity test,virulence factor evaluation,plasmid analysis and Different Region (DFR)genotyping.Results Qing-Tibet Plateau ecotype and Gangdis Mountain ecotype was 11 and 17 strains,respectively.Genomovar5 and genomovar19 was 2 and 26 strains,respectively.The strains had two kinds of plasmid spectrum-6 × 106,45 × 106,65 × 106 and 6 × 106,36 × 106,45 × 106,65 × 106,and the last one was newly discovered plasmid spectrum.All the 28 strains could produce F1,and Pst Ⅰ positive strains were 96.4% (27/28),VW positive strains were 32.1% (9/28),and pgm positive strains were 46.4% (13/28); 11 typical strains were selected to do the toxicity test,and 81.8% (9/11) were velogenic strains.Conclusions Strains separated in the south of Tibet from 1999 to 2008 have the characteristics of Qinghai-Tibet plateau plague's pathogen,and the strains' toxicity are strong.Therefore,we should enhance the plague monitoring to prevent animal plague spreading to human.