CAJ | 학술논문

目的：：探讨丙种球蛋白治疗重症手足口病的疗效。方法：选择重症手足口病患儿42例,随机分为常规治疗组20例；丙种球蛋白治疗组22例,其中又分为单纯丙种球蛋白治疗(单纯治疗组)14例和甲泼尼龙与丙种球蛋白联合治疗(联合治疗组)8例。比较3组临床疗效。结果：与常规治疗组比较,联合治疗组和单纯治疗组体温恢复、皮疹消退和神经系统症状改善时间均明显缩短(P<0.01)。常规治疗组中7例无效或进展为危重症,联合治疗组中无进展或无效病例,单纯治疗组有1例进展为危重病例,3组无效或进展病例数差异有统计学意义(P<0.05)。结论：丙种球蛋白治疗重症手足口病能够缩短病程,改善预后。
목적：：탐토병충구단백치료중증수족구병적료효。방법：선택중증수족구병환인42례,수궤분위상규치료조20례；병충구단백치료조22례,기중우분위단순병충구단백치료(단순치료조)14례화갑발니룡여병충구단백연합치료(연합치료조)8례。비교3조림상료효。결과：여상규치료조비교,연합치료조화단순치료조체온회복、피진소퇴화신경계통증상개선시간균명현축단(P<0.01)。상규치료조중7례무효혹진전위위중증,연합치료조중무진전혹무효병례,단순치료조유1례진전위위중병례,3조무효혹진전병례수차이유통계학의의(P<0.05)。결론：병충구단백치료중증수족구병능구축단병정,개선예후。
Objective:To explore the curative effects of intravenous immunoglobulin( IVGV) in the treatment of the sever hand-foot-mouth disease(HFMD). Methods:Forty-two clildren with sever HFMD were divided into the conventional therapy group(20 cases) and immunoglobulin therapy group( 22 cases ) . The immunoglobulin therapy group included 14 cases treated with single immunoglobulin (single therapy group) and 8 cases treated with immunoglobulin combined with methylprednisolone(combination therapy group). The curative effects between three groups were compared. Results:Compared with the conventional therapy group, the times of body temperature recovery, deflorescence and nervous system symptom improvement in the combination and single therapy groups were significantly shorter(P<0. 01). The invalid or progress for the critical illness in 7 cases in the conventional therapy group,no invalid or progress case in the combination therapy group, and progress for the critical illness in 1 case in single therapy group were found. Compared with the conventional therapy group,the failed or progress case in single therapy group was less(P<0. 05). Conclusions:The IVGV treatment can shorten the course and improve the prognosis of children with sever HFMD.