CAJ | 학술논문

幽门螺杆菌是引起胃癌的病因之一。幽门螺杆菌能引起胃黏膜炎症因子聚集，损伤胃黏膜；并通过多种途径激活上皮细胞内多个致瘤通路，包括磷脂酰肌醇3激酶（ PI3K）途径、Wnt-β连环蛋白和环氧化合酶-2（COX-2）-前列腺素E2抗体（PGE2）途径等，从而改变胃干细胞的微环境并扰乱胃干细胞的分化和增殖，使正常胃干细胞演变为癌症干细胞。
유문라간균시인기위암적병인지일。유문라간균능인기위점막염증인자취집，손상위점막；병통과다충도경격활상피세포내다개치류통로，포괄린지선기순3격매（ PI3K）도경、Wnt-β련배단백화배양화합매-2（COX-2）-전렬선소E2항체（PGE2）도경등，종이개변위간세포적미배경병우란위간세포적분화화증식，사정상위간세포연변위암증간세포。
Helicobacter pylori is one of causes of gastric cancer. It can cause mucosal inflammation cytokines aggregation,gastric mucosal damage;and through a variety of ways to activate epithelial cells multiple oncogenic pathways,including phosphatidylinositol 3 kinase( PI3K)pathway,Wnt-β-catenin and epoxidized synthase-2(COX-2)-prostaglandin E2 antibody(PGE2)pathway,so as to change the gastric stem cell micro-environment and disrupt the gastric stem cell differentiation and proliferation,making the normal gastric stem cells evolved into cancer stem cells.