基于静息态功能磁共振成像的慢性嗜酒者双侧杏仁核全脑功能连接研究
기우정식태공능자공진성상적만성기주자쌍측행인핵전뇌공능련접연구
Whole brain functional connectivity of the bilateral amygdaloid in chronic alcoholics: a resting-state functional magnetic resonance imaging study
  • 万方数据
    中华神经医学杂志 중화신경의학잡지
    CHINESE JOURNAL OF NEUROMEDICINE
    2015年 4期 495-500 ,共6页

    赵益林%陈军%刘金欢%林雪%吴汉斌%徐良洲%许启仲%刘昌盛%邱丽

    조익림%진군%류금환%림설%오한빈%서량주%허계중%류창성%구려

    慢性嗜酒%静息态MRI%杏仁核%功能连接 慢性嗜酒%靜息態MRI%杏仁覈%功能連接
    만성기주%정식태MRI%행인핵%공능련접
    Chronic alcoholics%Resting state functional magnetic resonance imaging%Amygdaloid%Functional connectivity
    目的 探讨慢性嗜酒者静息状态下的双侧杏仁核全脑功能连接(FC)情况.方法 选取33名慢性嗜酒者(慢性嗜酒组)及36名性别、年龄、受教育程度与之相匹配的健康志愿者(正常对照组),所有被试者均完成密歇根酒精筛查量表(MAST)和酒精成瘾量表(ADS)评分;使用MRI采集所有被试的静息态数据;数据处理及统计分析采用统计参数图(SPM5)及REST运行环境下的DPARSF软件.利用REST软件分别取得左侧杏仁核活性峰值体素(-24,0,-16)和右侧杏仁核峰值体素(24,0,16)作为种子点,得到全脑FC统计图;对2组FC预处理数据行双样本t检验,将受试者差异具有统计学意义的资料作为协变量.采用REST软件Slice Viewer功能查看结果,将经过Alphasim多重比较校正(FWHM=4,rmm=4,P=0.050)得到的连续体素＞54个体素(1458 mm3)的脑区定义为差异有统计学意义的区域;记录各脑区的峰值蒙特利尔神经科学研究所(MNI)坐标,查看其具体解剖位置;分别提取各脑区的时间序列,与MAST、ADS量表评分作相关性分析.结果 经头动检测,共12例(正常对照组7例,慢性嗜酒组5例)被试者数据被剔除,最终纳入57例被试者(正常对照组29例,慢性嗜酒组28例).以左侧杏仁核为种子点,与正常对照组相比,慢性嗜酒组静息态下FC增强的脑区有左侧额下回岛盖部、双侧缘上回、左侧丘脑、双侧中央旁小叶、左侧中央前回、右侧额下回眶部、右侧颞上回,差异有统计学意义(P＜0.05),功能连接减弱的脑区有左侧枕中回、左侧小脑脚、左侧眶额区、左侧嗅皮层、右侧小脑下半月小叶、右侧小脑顶叶、右侧额上回,差异有统计学意义(P＜0.05).以右侧杏仁核为种子点,与正常对照组相比,慢性嗜酒组静息态下FC增强的脑区有左侧额下回三角部、左侧颞中回、左侧尾状核、左侧楔前叶、左侧中央旁小叶、左侧额中回、右侧角回,差异有统计学意义(P＜0.05),FC减弱的脑区有左侧小脑半球、左侧额眶区、右侧顶上回、延髓,差异有统计学意义(P＜0.05);其中,慢性嗜酒组左侧额叶与MAST量表评分呈显著负相关(r=-0.433,P=0.021),而左侧楔前叶(r=0.245,P=0.210)、左侧侧缘上回(r=0.187,P=0.341)、右侧缘上回(r=0.142,P=0.4713)、右侧小脑(r=0.227,P=0.245)与ADS量表评分呈显著正相关.结论 慢性嗜酒者左侧杏仁核功能更易受损;杏仁核可能参与前额叶-小脑环路的功能调节,并与酒精相关性脑损害发病机制和临床表现密切相关.
    목적 탐토만성기주자정식상태하적쌍측행인핵전뇌공능련접(FC)정황.방법 선취33명만성기주자(만성기주조)급36명성별、년령、수교육정도여지상필배적건강지원자(정상대조조),소유피시자균완성밀헐근주정사사량표(MAST)화주정성은량표(ADS)평분;사용MRI채집소유피시적정식태수거;수거처리급통계분석채용통계삼수도(SPM5)급REST운행배경하적DPARSF연건.이용REST연건분별취득좌측행인핵활성봉치체소(-24,0,-16)화우측행인핵봉치체소(24,0,16)작위충자점,득도전뇌FC통계도;대2조FC예처리수거행쌍양본t검험,장수시자차이구유통계학의의적자료작위협변량.채용REST연건Slice Viewer공능사간결과,장경과Alphasim다중비교교정(FWHM=4,rmm=4,P=0.050)득도적련속체소＞54개체소(1458 mm3)적뇌구정의위차이유통계학의의적구역;기록각뇌구적봉치몽특리이신경과학연구소(MNI)좌표,사간기구체해부위치;분별제취각뇌구적시간서렬,여MAST、ADS량표평분작상관성분석.결과 경두동검측,공12례(정상대조조7례,만성기주조5례)피시자수거피척제,최종납입57례피시자(정상대조조29례,만성기주조28례).이좌측행인핵위충자점,여정상대조조상비,만성기주조정식태하FC증강적뇌구유좌측액하회도개부、쌍측연상회、좌측구뇌、쌍측중앙방소협、좌측중앙전회、우측액하회광부、우측섭상회,차이유통계학의의(P＜0.05),공능련접감약적뇌구유좌측침중회、좌측소뇌각、좌측광액구、좌측후피층、우측소뇌하반월소협、우측소뇌정협、우측액상회,차이유통계학의의(P＜0.05).이우측행인핵위충자점,여정상대조조상비,만성기주조정식태하FC증강적뇌구유좌측액하회삼각부、좌측섭중회、좌측미상핵、좌측설전협、좌측중앙방소협、좌측액중회、우측각회,차이유통계학의의(P＜0.05),FC감약적뇌구유좌측소뇌반구、좌측액광구、우측정상회、연수,차이유통계학의의(P＜0.05);기중,만성기주조좌측액협여MAST량표평분정현저부상관(r=-0.433,P=0.021),이좌측설전협(r=0.245,P=0.210)、좌측측연상회(r=0.187,P=0.341)、우측연상회(r=0.142,P=0.4713)、우측소뇌(r=0.227,P=0.245)여ADS량표평분정현저정상관.결론 만성기주자좌측행인핵공능경역수손;행인핵가능삼여전액협-소뇌배로적공능조절,병여주정상관성뇌손해발병궤제화림상표현밀절상관.
    Objective To explore the conditions of whole brain functional connectivity (FC) of the bilateral amygdaloid in resting state in chronic alcoholics.Methods Thirty-three chronic alcoholics and 36 healthy control subjects matched in gender,age,education and handedness,admitted to our hospital from October 2011 to October 2012,were enrolled as chronic alcoholics group and control group,respectively.All subjects were asked to perform both Michigan alcohol screening scale (MAST) and alcohol addiction scale (ADS) to ensure that the alcohol dependent individuals enrolled in this study reached moderate alcohol dependent.All subjects were performed MR imaging;DPARSF software was used to perform data processing which was based on MATLABE,SPM and REST operating environment.REST software was made use of the left amygdala activity peak voxel (-24,0,-16) and right amygdala peak voxel (24,0,16) as seeded region of interest to get the whole brain FC mapping.Rest Slice Viewer software within REST software package was used to view statistical results.Each time series of brain regions were extracted,and correlation analysis of MAST scores with ADS scores was performed and the corresponding correlation coefficient values were recorded.Results Finally,57 subjects (28 in chronic alcoholics group and 29 in control group) were enrolled after screening.As compared with that in the healthy controls,the FC of left pars opercularis gyri frontalis inferiorista,bilateral supramarginal gyrus,left thalamus,bilateral paracentral lobule,left precentral gyrus,right pars orbitalis gyri frontalis inferiois and right superior temporal gyrus was significantly increased in the left amygdaloid,and that of left middle occipital gyrus,left cerebellar peduncle,left orbitofrontal region,left entorhinal cortex,right cerebellum inferior semi-Lunar lobule,right cerebellar parietal and superior frontal gyrus was significantly decreased in resting state in chronic alcoholism (P＜0.05);as compared with that in the control group,the FC of left pars triangularis gyri frontalis inferiorista,left middle temporal gyrus,left caudate nucleus,left precuneus,left paracentral lobule,left middle frontal gyrus and right angular gyrus was significantly increased in the right amygdaloid,and that of left cerebellar hemisphere,left orbifrontal area,right superior parietal lobule,medulla oblongata was significantly decreased in resting state in chronic alcoholism (P＜0.05).In the chronic alcoholics group,the left frontal lobe was significantly negatively correlated with MAST scores (r=-0.433,P=0.021);the left precuneus (r=0.245,P=0.210),left supramarginal gyrus(r=0.187,P=0.341),right supramarginal gyrus(r=0.142,P=0.471) and right cerebellum (r=0.227,P=0.245) showed a significant positive correlation with ADS scores.Conclusion Left amygdale's function of chronic alcoholics is more easily damaged;amygdala may be involved in regulating the function of fronto-cerebellar loops,and has close relation with alcohol-related brain damage in the pathogenesis and clinical manifestations.
    원문보기 원문다운로드 사이트로이동
저자의 최근 논문