国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2015年
4期
249-251
,共3页
食管肿瘤%放射疗法%药物疗法
食管腫瘤%放射療法%藥物療法
식관종류%방사요법%약물요법
Esophageal neoplasms%Radiotherapy%Drug therapy
目的：评价三维适形放疗同步化疗治疗进展期食管癌的近期疗效及不良反应。方法回顾性分析我科2008年1月至2011年1月的127例进展期食管鳞状细胞癌患者，分为同步放化疗组（69例）和单纯放疗组（58例）。观察两组的不良反应、生命质量及近期疗效。结果同步放化疗组白细胞下降和放射性食管炎的严重比例均明显高于单纯放疗组（29.0%：12.1%，χ2=5.387，P =0.020；24.6%：10.3%，χ2=4.341，P =0.037）；生命质量，尤其是消化道不良反应（恶心、呕吐、腹泻）及进食量下降方面，同步放化疗组的患者的比例均明显高于单纯放疗组（73.9%：12.1%，χ2=48.574，P =0.000；43.5%：25.9%，χ2=4.274，P =0.039）；同步放化疗组有效率91.30%，单纯放疗组72.41%，差异有统计学意义（χ2=7.852，P =0.005）。结论三维适形放疗同步化疗治疗进展期食管癌有较好的近期疗效，但不良反应也有所增加，长期疗效有待进一步观察。
目的：評價三維適形放療同步化療治療進展期食管癌的近期療效及不良反應。方法迴顧性分析我科2008年1月至2011年1月的127例進展期食管鱗狀細胞癌患者，分為同步放化療組（69例）和單純放療組（58例）。觀察兩組的不良反應、生命質量及近期療效。結果同步放化療組白細胞下降和放射性食管炎的嚴重比例均明顯高于單純放療組（29.0%：12.1%，χ2=5.387，P =0.020；24.6%：10.3%，χ2=4.341，P =0.037）；生命質量，尤其是消化道不良反應（噁心、嘔吐、腹瀉）及進食量下降方麵，同步放化療組的患者的比例均明顯高于單純放療組（73.9%：12.1%，χ2=48.574，P =0.000；43.5%：25.9%，χ2=4.274，P =0.039）；同步放化療組有效率91.30%，單純放療組72.41%，差異有統計學意義（χ2=7.852，P =0.005）。結論三維適形放療同步化療治療進展期食管癌有較好的近期療效，但不良反應也有所增加，長期療效有待進一步觀察。
목적：평개삼유괄형방료동보화료치료진전기식관암적근기료효급불량반응。방법회고성분석아과2008년1월지2011년1월적127례진전기식관린상세포암환자，분위동보방화료조（69례）화단순방료조（58례）。관찰량조적불량반응、생명질량급근기료효。결과동보방화료조백세포하강화방사성식관염적엄중비례균명현고우단순방료조（29.0%：12.1%，χ2=5.387，P =0.020；24.6%：10.3%，χ2=4.341，P =0.037）；생명질량，우기시소화도불량반응（악심、구토、복사）급진식량하강방면，동보방화료조적환자적비례균명현고우단순방료조（73.9%：12.1%，χ2=48.574，P =0.000；43.5%：25.9%，χ2=4.274，P =0.039）；동보방화료조유효솔91.30%，단순방료조72.41%，차이유통계학의의（χ2=7.852，P =0.005）。결론삼유괄형방료동보화료치료진전기식관암유교호적근기료효，단불량반응야유소증가，장기료효유대진일보관찰。
Objective To evaluate the clinical efficacy and toxicities of three dimensional conformal radiotherapy combined with chemotherapy for advanced esophageal carcinoma. Methods We retrospectively reviewed 127 patients with advanced esophageal squamous carcinoma in our department from January 2008 to January 2011,who were divided into two groups:conformal radiotherapy combined with chemotherapy(RCT) group,69 patients and radiotherapy(RT)group,58 patients. The side effects,quality of life and effective rates of them were compared. Results The severe rate of the marrow toxic effect and the incidences of radia-tion-induced esophagitis were higher in the RCT group(29. 0% vs 12. 1% ,χ2 = 5. 387,P = 0. 020;24. 6% vs 10. 3% ,χ2 = 4. 341,P = 0. 037). Patients in the RT group had better quality of life than those in the RCT group in gastrointestinal side effects(nausea,vomiting,diarrhea)and food intake(73. 9% vs 12. 1% ,χ2 =48. 574,P = 0. 000;43. 5% vs 25. 9% ,χ2 = 4. 274,P = 0. 039). In the RCT group,the effective rate was 91. 30%(63 / 69)and 72. 41 %(42 / 58)in the RT group,with a statistical significance(χ2 = 7. 852,P =0. 005). Conclusion Three dimensional conformal radiotherapy combined with chemotherapy for advanced esophageal carcinoma can improve the short-term curative effects,but it also increase the acute toxic effect. Further follow-up studies are needed for its long-term effect.
