CAJ | 학술논문

与正常细胞相比，肿瘤细胞因其基因或者表观遗传的改变，导致许多代谢通路发生紊乱。正常细胞发生恶化过程中，不仅糖代谢通路发生异常，线粒体生物合成、氨基酸代谢、脂代谢等其他代谢通路也会发生变化。这些代谢变化对肿瘤的发生发展以及临床靶向治疗具有重要的意义。
여정상세포상비，종류세포인기기인혹자표관유전적개변，도치허다대사통로발생문란。정상세포발생악화과정중，불부당대사통로발생이상，선립체생물합성、안기산대사、지대사등기타대사통로야회발생변화。저사대사변화대종류적발생발전이급림상파향치료구유중요적의의。
Compared to normal counterparts,cancer cells exhibit metabolic changes owing to both genetic and epigenetic alterations. Some abnormal alterations happen in tumor cells including glycolysis,mito-chondrial biogenesis,glutaminolysis and lipid synthesis. These metabolic changes have great significance to development of tumor and clinical targeted therapies.