CAJ | 학술논문

B 细胞特异的莫洛尼白血病毒插入位点1（Bmi-1）基因是多梳基因家族的核心成员之一，被认为是一种原癌基因，在细胞的自我更新、增殖及凋亡方面发挥重要作用。研究证实，Bmi-1的高表达与非小细胞肺癌的发生、发展、侵袭及预后密切相关。Bmi-1基因有望成为一种新的肿瘤分子标志物，为非小细胞肺癌的诊断、靶向治疗提供新的方向。
B 세포특이적막락니백혈병독삽입위점1（Bmi-1）기인시다소기인가족적핵심성원지일，피인위시일충원암기인，재세포적자아경신、증식급조망방면발휘중요작용。연구증실，Bmi-1적고표체여비소세포폐암적발생、발전、침습급예후밀절상관。Bmi-1기인유망성위일충신적종류분자표지물，위비소세포폐암적진단、파향치료제공신적방향。
B-cell specific moloney leukemia virus insertion site 1(Bmi-1)gene is a core member of the polycomb group genes,considered to be a proto-oncogene;Bmi-1 plays an important role in cell self-renewal, proliferation and apoptosis. Several studies have shown that Bmi-1 is highly expressed in non-small cell lung cancer;furthermore,the expression level of Bmi-1 is closely related to the occurrence,development,incursion and prognosis of non-small cell lung cancer. Bmi-1 is expected to become a novel tumor molecular marker,and provides a new direction for the treatment of non-small cell lung cancer.