CAJ | 학술논문

肿瘤间质比（TSR）指肿瘤组织内肿瘤细胞与间质部分的比例，可通过对苏木素-伊红染色的病理切片进行评估得到。通常以50%作为截断值，将病例分为间质丰富组（TSR <50%）及间质稀少组（TSR≥50%），从而比较两组患者的预后差异。当前研究结果表明，在结直肠癌、乳腺癌、食管癌、宫颈癌和非小细胞肺癌中，TSR 是肿瘤预后的独立影响因子，肿瘤间质丰富的患者预后更差，原因可能为肿瘤细胞能活化间质细胞，而活化的间质细胞又能促进肿瘤的生长、浸润及转移，间质组织在肿瘤的进展及侵袭过程中起着必不可少的作用。
종류간질비（TSR）지종류조직내종류세포여간질부분적비례，가통과대소목소-이홍염색적병리절편진행평고득도。통상이50%작위절단치，장병례분위간질봉부조（TSR <50%）급간질희소조（TSR≥50%），종이비교량조환자적예후차이。당전연구결과표명，재결직장암、유선암、식관암、궁경암화비소세포폐암중，TSR 시종류예후적독립영향인자，종류간질봉부적환자예후경차，원인가능위종류세포능활화간질세포，이활화적간질세포우능촉진종류적생장、침윤급전이，간질조직재종류적진전급침습과정중기착필불가소적작용。
Tumor-stroma ratio is the ratio of tumor cells and stromal tissue. It can be evaluated through HE-stained sections. Usually a 50% cut-off value is taken. TSR is stratified as stroma rich(TSR < 50% )and stroma poor(TSR≥50% ). The different prognosis between the two groups can be assessed. Several previous studies show that TSR is an independent prognostic factor for colon carcinoma,breast cancer,esophageal squa-mous cell carcinoma,cervical carcinoma and non-small cell lung cancer;patients with stroma-rich tumor suffer worse prognosis. The cause might be that tumor cells could activate stroma cells while activated stroma cells could promote the growth,infiltration and metastasis of tumors. And tumor stroma should be recognized as an indispensible participant in progression and invasion of carcinoma.