CAJ | 학술논문

二甲双胍作为一种廉价安全高效的糖尿病药物已应用多年，近年来研究显示其对各种肿瘤细胞都有不同程度的抑制作用。二甲双胍的抗肿瘤机制尚未完全明确，可能与糖代谢及蛋白激酶途径有关，也可能与炎症因子介导肿瘤杀伤有关。二甲双胍对不同肿瘤细胞杀伤效果不同，对其他抗肿瘤治疗也有一些辅助作用。
이갑쌍고작위일충렴개안전고효적당뇨병약물이응용다년，근년래연구현시기대각충종류세포도유불동정도적억제작용。이갑쌍고적항종류궤제상미완전명학，가능여당대사급단백격매도경유관，야가능여염증인자개도종류살상유관。이갑쌍고대불동종류세포살상효과불동，대기타항종류치료야유일사보조작용。
Metformin as a cheap,safe and effective diabetes drug,has been used for many years. Recently,many studies have shown its variety inhibition of tumor cells. Its antitumor mechanism is not entirely clear;may be related to glucose metabolism and protein kinase or inflammatory cytokines mediating tumor kill-ing. Metformin has different cytotoxic effects to various tumor cell,as well as playing some auxiliary roles on other antitumor methods.