中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2015年
4期
224-232
,共9页
高尿酸血症%痛风%亚甲基四氢叶酸还原酶%多态性,单核苷酸%Meta分析
高尿痠血癥%痛風%亞甲基四氫葉痠還原酶%多態性,單覈苷痠%Meta分析
고뇨산혈증%통풍%아갑기사경협산환원매%다태성,단핵감산%Meta분석
Hyperuricemia%Gout%Methylenetetrahydrofolate reductase%Polymorphism,single nucleotide%Meta analysis
目的 探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T位点单核苷酸多态性(SNP)与高尿酸血症(HUM)及痛风易感性的关联情况.方法 通过中国生物医学文献数据库、中国期刊网全文数据库、万方、维普、PubMed、Cochrane Library 、OvidSP、Wiley Online Librau、EBSCO、Elsevier Science Direct、Springer Link、Google scholar数据库检索MTHFR基因C677T位点SNP 1j HUM、痛风相关的病例-对照研究,利用RevMan 5.3和Stata 12.0软件,根据异质性大小选用随机效应或固定效应模型对各研究数据进行综合统计分析 结果 共纳入10篇HUM文献,包括1 899例患者和5 403例对照;3篇痛风文献,包括209例患者和194例对照HUM的Meta分析结果提示携有CC基因型[比值比(OR)=0.42,95％CI(0.29,0.63),P＜0.01]和C等位基因[OR=0.54,95％CI (0.42,0.71),P＜0.01]的人群罹患HUM的风险降低,携有TT基因型[OR=1.55,95％CI (1.32,1.83),P＜0.01]和T等位基因[OR =1.84,95％CI (1.38,2.45),P＜0.01]的人群罹患HUM的风险增高痛风的Meta分析结果提示携有CC基因型[OR=0.32,95％CI(0.15,0.68),P=0.003]和C等位基因[OR=0.35,95％CI (0.17,0.70),P=0.003]的人群罹患痛风的风险降低,携有TT基因型[OR =2.92,95％CI(1.74,4.92),P＜0.01]和T等位基因[OR=2.69,95％CI(1.50,4.84),P=0.000 9]的人群罹患痛风的风险增高.结论 MTHFR基因C677T位点SNP与HUM、痛风易感性之间有关联性.
目的 探討亞甲基四氫葉痠還原酶(MTHFR)基因C677T位點單覈苷痠多態性(SNP)與高尿痠血癥(HUM)及痛風易感性的關聯情況.方法 通過中國生物醫學文獻數據庫、中國期刊網全文數據庫、萬方、維普、PubMed、Cochrane Library 、OvidSP、Wiley Online Librau、EBSCO、Elsevier Science Direct、Springer Link、Google scholar數據庫檢索MTHFR基因C677T位點SNP 1j HUM、痛風相關的病例-對照研究,利用RevMan 5.3和Stata 12.0軟件,根據異質性大小選用隨機效應或固定效應模型對各研究數據進行綜閤統計分析 結果 共納入10篇HUM文獻,包括1 899例患者和5 403例對照;3篇痛風文獻,包括209例患者和194例對照HUM的Meta分析結果提示攜有CC基因型[比值比(OR)=0.42,95％CI(0.29,0.63),P＜0.01]和C等位基因[OR=0.54,95％CI (0.42,0.71),P＜0.01]的人群罹患HUM的風險降低,攜有TT基因型[OR=1.55,95％CI (1.32,1.83),P＜0.01]和T等位基因[OR =1.84,95％CI (1.38,2.45),P＜0.01]的人群罹患HUM的風險增高痛風的Meta分析結果提示攜有CC基因型[OR=0.32,95％CI(0.15,0.68),P=0.003]和C等位基因[OR=0.35,95％CI (0.17,0.70),P=0.003]的人群罹患痛風的風險降低,攜有TT基因型[OR =2.92,95％CI(1.74,4.92),P＜0.01]和T等位基因[OR=2.69,95％CI(1.50,4.84),P=0.000 9]的人群罹患痛風的風險增高.結論 MTHFR基因C677T位點SNP與HUM、痛風易感性之間有關聯性.
목적 탐토아갑기사경협산환원매(MTHFR)기인C677T위점단핵감산다태성(SNP)여고뇨산혈증(HUM)급통풍역감성적관련정황.방법 통과중국생물의학문헌수거고、중국기간망전문수거고、만방、유보、PubMed、Cochrane Library 、OvidSP、Wiley Online Librau、EBSCO、Elsevier Science Direct、Springer Link、Google scholar수거고검색MTHFR기인C677T위점SNP 1j HUM、통풍상관적병례-대조연구,이용RevMan 5.3화Stata 12.0연건,근거이질성대소선용수궤효응혹고정효응모형대각연구수거진행종합통계분석 결과 공납입10편HUM문헌,포괄1 899례환자화5 403례대조;3편통풍문헌,포괄209례환자화194례대조HUM적Meta분석결과제시휴유CC기인형[비치비(OR)=0.42,95％CI(0.29,0.63),P＜0.01]화C등위기인[OR=0.54,95％CI (0.42,0.71),P＜0.01]적인군리환HUM적풍험강저,휴유TT기인형[OR=1.55,95％CI (1.32,1.83),P＜0.01]화T등위기인[OR =1.84,95％CI (1.38,2.45),P＜0.01]적인군리환HUM적풍험증고통풍적Meta분석결과제시휴유CC기인형[OR=0.32,95％CI(0.15,0.68),P=0.003]화C등위기인[OR=0.35,95％CI (0.17,0.70),P=0.003]적인군리환통풍적풍험강저,휴유TT기인형[OR =2.92,95％CI(1.74,4.92),P＜0.01]화T등위기인[OR=2.69,95％CI(1.50,4.84),P=0.000 9]적인군리환통풍적풍험증고.결론 MTHFR기인C677T위점SNP여HUM、통풍역감성지간유관련성.
Objective To explore the association between C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to hyperuricemia and gout.Methods The case-control studies from Chinese Biomedical Database,Chinese National Knowledge Infrastructure,Wanfang,Weipu,PubMed,Cochrane Library,OvidSP,Wiley Online Library,EBSCO,Elsevier Science Direct,Springer Link and Google scholar databases for the association of C677T polymorphism of MTHFR gene with hyperuricemia and gout.The pooled odds ratios (OR) with 95％ confidence intervals (CI) were appropriately derived from randomeffects or fixed-effects models to assess the association strength by RevMan 5.3 and Stata 12.0 software.Results Ten references enrolled 1 899 hyperuricemia patients and 5 403 controls,and 3 references enrolled 209 gout patients and 194 controls in total.The meta analysis showed that carriers of genotype CC [OR=0.42,95％CI (0.29,0.63),P＜0.01] and allele C [OR=0.54,95％CI (0.42,0.71),P＜0.01] had lower risk of hyperuricemia;genotype TT [OR=1.55,95％CI (1.32,1.83),P＜0.01] and allele T [OR=1.84,95％CI (1.38,2.45),P＜0.01] had higher risk of hyperuricemia,carriers of genotype CC [OR=0.32,95％CI (0.15,0.68),P=0.003] and allele C [OR=0.35,95％CI (0.17,0.70),P=0.003] hadlower risk of gout;genotype TT [OR=2.92,95％CI (1.74,4.92),P＜0.01] allele T [OR=2.69,95％CI(1.50,4.84),P=0.0009] had higher risk of gout.Conclusion The meta analysis reveals that C677T polymorphism of MTHFR gene is associated with the susceptibility to hyperuricemia and gout.
