CAJ | 학술논문

目的：探讨苯磺酸左旋氨氯地平联合依那普利治疗原发性高血压的疗效及安全性。方法选取2009年10月—2011年10月攀枝花市仁和区大河中路社区卫生服务中心收治的原发性高血压患者120例。根据高血压患者个体情况（年龄、身体状况、体质等）不同，采用适当剂量的苯磺酸左旋氨氯地平联合依那普利治疗。观察并记录所有患者治疗前及治疗2个月后血压控制情况，临床症状发生情况，心、脑、肾靶器官受损情况及心脑血管事件发生情况。结果血压控制总有效率为90.8%；患者临床症状完全消失87例（72.5%）；治疗后患者头痛、乏力、头晕、眼花、耳鸣、注意力不集中、失眠发生率低于治疗前，差异均有统计学意义（P ＜0.05）；靶器官损伤恢复率为61.5%；心脑血管事件发生率为2.5%。结论苯磺酸左旋氨氯地平联合依那普利治疗原发性高血压的疗效显著，可保护靶器官功能，且心脑血管事件发生率低，安全性高。
목적：탐토분광산좌선안록지평연합의나보리치료원발성고혈압적료효급안전성。방법선취2009년10월—2011년10월반지화시인화구대하중로사구위생복무중심수치적원발성고혈압환자120례。근거고혈압환자개체정황（년령、신체상황、체질등）불동，채용괄당제량적분광산좌선안록지평연합의나보리치료。관찰병기록소유환자치료전급치료2개월후혈압공제정황，림상증상발생정황，심、뇌、신파기관수손정황급심뇌혈관사건발생정황。결과혈압공제총유효솔위90.8%；환자림상증상완전소실87례（72.5%）；치료후환자두통、핍력、두훈、안화、이명、주의력불집중、실면발생솔저우치료전，차이균유통계학의의（P ＜0.05）；파기관손상회복솔위61.5%；심뇌혈관사건발생솔위2.5%。결론분광산좌선안록지평연합의나보리치료원발성고혈압적료효현저，가보호파기관공능，차심뇌혈관사건발생솔저，안전성고。
Objective To explore the clinical efficacy and safety of levamlodipine besylate and enalapril in treatment of essential hypertension. Methods A total of 120 patients with essential hypertension in Renhe River Road Community Health Service Center from October 2009 to October 2011 were selected. According to the individual of situation(age,physical condi-tion,physical),they were given appropriate doses of levamlodipine besylate and enalapril. Before and 2 months after treat-ment,blood pressure,clinical symptoms,heart,brain and kidney target organ damage and cardiovascular events were ob-served. Results Total effective blood pressure control rate was 90. 8% . Patients with clinical symptoms disappear altogether had 87 cases(72. 5% ). After treatment,occurrence rate of headache,fatigue,dizziness,vertigo,tinnitus,inattention,in-somnia incidence of patients were lower than before the treatment(P < 0. 05). Target organ recovery rate was 61. 5% . The in-cidence of cardiovascular events was 2. 5% . Conclusion Levamlodipine besylate and enalapril has notable curative effect in the treatment of essential hypertension,can protect target organs function,has low incidence of cardiovascular events,and high safety.