CAJ | 학술논문

目的：研究比索洛尔治疗原发性高血压的临床疗效及对左心功能的影响。方法选择2012—2013年湖州市七里亭新村社区卫生服务站收治的150例原发性高血压患者，分为比索洛尔组83例和氯沙坦组67例。患者治疗前后行心脏彩超检查，记录治疗前后的每搏输出量（SV）、心排血量（CO）、左心室射血分数（LVEF）、左心室缩短分数（LVFS）及左室舒张早期血流峰值（E 峰）速度、舒张晚期血流峰值（A 峰）速度，计算 E 峰/ A 峰比值（E/ A）。结果比索洛尔组总有效率为94.0%，高于氯沙坦组的85.1%，差异有统计学意义（P ＜0.05）。治疗后比索洛尔组 E/ A 值高于氯沙坦组，差异有统计学意义（P ＜0.05）。结论比索洛尔治疗原发性高血压的疗效确切，可有效改善左心室的舒张功能。
목적：연구비색락이치료원발성고혈압적림상료효급대좌심공능적영향。방법선택2012—2013년호주시칠리정신촌사구위생복무참수치적150례원발성고혈압환자，분위비색락이조83례화록사탄조67례。환자치료전후행심장채초검사，기록치료전후적매박수출량（SV）、심배혈량（CO）、좌심실사혈분수（LVEF）、좌심실축단분수（LVFS）급좌실서장조기혈류봉치（E 봉）속도、서장만기혈류봉치（A 봉）속도，계산 E 봉/ A 봉비치（E/ A）。결과비색락이조총유효솔위94.0%，고우록사탄조적85.1%，차이유통계학의의（P ＜0.05）。치료후비색락이조 E/ A 치고우록사탄조，차이유통계학의의（P ＜0.05）。결론비색락이치료원발성고혈압적료효학절，가유효개선좌심실적서장공능。
Objective To evaluate the clinical effect and impact on left ventricular function of bisoprolol in treatment of primary hypertension. Methods A total of 83 primary hypertension patients were selected in Qilitingxincun Community Health Service Station of Huzhou City from 2012 to 2013,they were divided into bisoprolol group(83 cases)and losartan group (67 cases). Bisoprolol group were treated with bisoprolol,losartan group were treated with losartan,patients were received echocardiography before and after treatment,stroke volume( SV),cardiac output( CO),left ventricular ejection fraction (LVEF),left ventricular shortening fraction(LVFS),left ventricular peak early diastolic blood flow velocity(E),late dias-tolic blood flow peak velocity(A)were recorded,E/ A was calculated. Results The total effective rate of bisoprolol group was 94. 0% ,was higher than losartan group of 85. 1% ,the difference was statistically significant(P < 0. 05). After treatment the E / A value of bisoprolol group was higher than losartan group(P < 0. 05). Conclusion Bisoprolol treating primary hyperten-sion has good clinical effect,can effectively improve the left ventricular diastolic function.