临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
13期
18-19
,共2页
侯杰%王淑伟%罗美怡%邱弛宇%李景云
侯傑%王淑偉%囉美怡%邱弛宇%李景雲
후걸%왕숙위%라미이%구이우%리경운
曲马多%昂丹司琼%预防%剖宫产%麻醉%寒颤%恶心呕吐
麯馬多%昂丹司瓊%預防%剖宮產%痳醉%寒顫%噁心嘔吐
곡마다%앙단사경%예방%부궁산%마취%한전%악심구토
Tramadol%Ondansetron%Prophylaxis%Cesarean section%Anaesthesia%Shivering%Nausea and vomiting
目的:观察曲马多联合昂丹司琼预防蛛网膜下腔麻醉后寒颤的临床效果。方法将120例行剖宫产的产妇随机分为观察组A、观察组B和对照组。麻醉开始前,观察组A缓慢静脉注射曲马多1mg/kg,观察组B缓慢静脉注射曲马多1mg/kg+昂丹司琼4mg,对照组给予生理盐水4ml。观察麻醉开始至手术结束4h内产妇寒颤、恶心呕吐、眩晕、低血压、呼吸抑制等不良反应情况和新生儿Apgar评分情况。结果观察组A和观察组B产妇寒颤发生率均低于对照组,差异均有统计学意义(P<0.05),观察组A恶心呕吐发生率高于观察组B和对照组,差异均有统计学意义(P<0.05),观察组B与对照组恶心呕吐发生率差异无统计学意义(P>0.05)。3组均未发生眩晕、呼吸抑制等,且术中低血压发生率3组间差异无统计学意义(P>0.05),3组新生儿Apgar评分组间差异无统计学意义(P>0.05)。结论曲马多联合昂丹司琼能有效预防蛛网膜下腔麻醉后的寒颤反应,且恶心呕吐的发生率较低。
目的:觀察麯馬多聯閤昂丹司瓊預防蛛網膜下腔痳醉後寒顫的臨床效果。方法將120例行剖宮產的產婦隨機分為觀察組A、觀察組B和對照組。痳醉開始前,觀察組A緩慢靜脈註射麯馬多1mg/kg,觀察組B緩慢靜脈註射麯馬多1mg/kg+昂丹司瓊4mg,對照組給予生理鹽水4ml。觀察痳醉開始至手術結束4h內產婦寒顫、噁心嘔吐、眩暈、低血壓、呼吸抑製等不良反應情況和新生兒Apgar評分情況。結果觀察組A和觀察組B產婦寒顫髮生率均低于對照組,差異均有統計學意義(P<0.05),觀察組A噁心嘔吐髮生率高于觀察組B和對照組,差異均有統計學意義(P<0.05),觀察組B與對照組噁心嘔吐髮生率差異無統計學意義(P>0.05)。3組均未髮生眩暈、呼吸抑製等,且術中低血壓髮生率3組間差異無統計學意義(P>0.05),3組新生兒Apgar評分組間差異無統計學意義(P>0.05)。結論麯馬多聯閤昂丹司瓊能有效預防蛛網膜下腔痳醉後的寒顫反應,且噁心嘔吐的髮生率較低。
목적:관찰곡마다연합앙단사경예방주망막하강마취후한전적림상효과。방법장120례행부궁산적산부수궤분위관찰조A、관찰조B화대조조。마취개시전,관찰조A완만정맥주사곡마다1mg/kg,관찰조B완만정맥주사곡마다1mg/kg+앙단사경4mg,대조조급여생리염수4ml。관찰마취개시지수술결속4h내산부한전、악심구토、현훈、저혈압、호흡억제등불량반응정황화신생인Apgar평분정황。결과관찰조A화관찰조B산부한전발생솔균저우대조조,차이균유통계학의의(P<0.05),관찰조A악심구토발생솔고우관찰조B화대조조,차이균유통계학의의(P<0.05),관찰조B여대조조악심구토발생솔차이무통계학의의(P>0.05)。3조균미발생현훈、호흡억제등,차술중저혈압발생솔3조간차이무통계학의의(P>0.05),3조신생인Apgar평분조간차이무통계학의의(P>0.05)。결론곡마다연합앙단사경능유효예방주망막하강마취후적한전반응,차악심구토적발생솔교저。
Objective To observe the clinical effect of tramadol with ondansetron on prophylaxis of shivering during spinal anaesthesia.Methods 120 patients undergoing cesarean section were randomly divided into the observation group A, observation group B and control group.Before the start of anesthesia,the observation group A was given slow intravenous injec-tion with tramadol 1 mg/kg,and the observation group B was given slow intravenous injection with tramadol 1 mg/kg and on-dansetron 4 mg,and the control group was given normal saline 4ml.From the start of anesthesia to the end of the operation,the chills,nausea and vomiting,dizziness,hypotension,respiratory depression and other adverse reaction and neonatal Apgar score of the three groups were observed.Results The incidence of shivering of observation group A and group B were lower than control group( P<0.05) .The incidence of nausea and vomiting of observation group A was higher than the observation group B and control groupt(P<0.05).The difference of incidence of nausea and vomiting between the observation group B and control group was not statistically significant(P>0.05).There were no statistically significant difference between the 3 groups inci-dence of intraoperative hypotension and neonatal Apgar score group(P>0.05).Conclusion Compared with tramadol 1 mg/kg,tramadol 1 mg/kg combined with ondansetron 4 mg can effectively prevent shivering after anesthesia,and the incidence of nausea and vomiting was low.