CAJ | 학술논문

目的：观察伏格列波糖治疗新发2型糖尿病（ T2DM）患者的疗效和安全性。方法将110例新发T2DM患者随机分为治疗组和对照组各55例。治疗组餐时口服伏格列波糖，对照组餐前口服格列齐特，治疗8周后比较2组患者空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbA1c），并观察其不良反应。结果2组治疗后FPG、2hPG、HbA1c均较治疗前明显下降，差异均有统计学意义（P＜0．05）；且治疗后治疗组2hPG、HbA1c均低于对照组，差异均有统计学意义（P＜0．05）。治疗后2组FPG比较差异无统计学意义（P＞0．05）。治疗组腹胀、肛门排气增多5例，腹泻2例，但症状较轻，患者可耐受，未发生低血糖；对照组腹胀4例，腹泻1例，低血糖3例。结论伏格列波糖治疗初发T2DM效果显著，且有良好的安全性。
목적：관찰복격렬파당치료신발2형당뇨병（ T2DM）환자적료효화안전성。방법장110례신발T2DM환자수궤분위치료조화대조조각55례。치료조찬시구복복격렬파당，대조조찬전구복격렬제특，치료8주후비교2조환자공복혈당（FPG）、찬후2h혈당（2hPG）、당화혈홍단백（HbA1c），병관찰기불량반응。결과2조치료후FPG、2hPG、HbA1c균교치료전명현하강，차이균유통계학의의（P＜0．05）；차치료후치료조2hPG、HbA1c균저우대조조，차이균유통계학의의（P＜0．05）。치료후2조FPG비교차이무통계학의의（P＞0．05）。치료조복창、항문배기증다5례，복사2례，단증상교경，환자가내수，미발생저혈당；대조조복창4례，복사1례，저혈당3례。결론복격렬파당치료초발T2DM효과현저，차유량호적안전성。
Objective To observe the efficacy and safety of voglibose therapy in newly diagnosed type 2 diabetes mel-litus ( T2DM) patients.Methods 110 patients with newly diagnosed T2DM were randomly divided into treatment group and control group,55 cases of each.The treatment group was given when the meal oral voglibose,and control group was given pre-meal oral gliclazide.After 8 weeks′treatment,compared FPG,2hPG,HbA1c of two groups,and observed adverse reactions of the two group.Results After treatment,FPG,2hPG,HbA1c of the two groups were significantly decreased than before,the differences were statistically significant(P<0.05);and 2hPG,HbA1c of treatment group were lower than that of control group, the difference were statistically significant(P<0.05).Difference of FPG in the 2 groups was not statistically significant(P>0.05).There are 5 cases with abdominal distension and anal exhaust increased, and 2 cases with diarrhea in the treatment group;There are 4 cases with abdominal distension,1 cases with diarrhea,3 cases with hypoglycemia in control group.The symptom of two groups were lighter,and the patients can tolerate.Conclusion For the patients with newly diagnosed T2DM, voglibose has a good efficacy and safety.