CAJ | 학술논문

目的：研究复方苦参注射液与帕米膦酸二钠联合使用于骨转移瘤疼痛治疗的疗效。方法将107例骨转移瘤患者随机分为治疗组和对照组，治疗组（n＝54）采用复方苦参注射液和帕米膦酸二钠联合治疗，对照组（n＝53）单用帕米膦酸二钠治疗；治疗2个周期后观察2组患者的止痛疗效、不良反应及血清碱性磷酸酶等变化。结果2组患者疼痛的缓解有效率（治疗组79．62％，对照组52．83％），血清碱性磷酸酶下降率（治疗组70．37％，对照组45．28％）比较，差异均有统计学意义（ P＜0．05）。结论复方苦参注射液联合帕米膦酸二钠治疗恶性肿瘤骨转移疼痛疗效肯定。
목적：연구복방고삼주사액여파미련산이납연합사용우골전이류동통치료적료효。방법장107례골전이류환자수궤분위치료조화대조조，치료조（n＝54）채용복방고삼주사액화파미련산이납연합치료，대조조（n＝53）단용파미련산이납치료；치료2개주기후관찰2조환자적지통료효、불량반응급혈청감성린산매등변화。결과2조환자동통적완해유효솔（치료조79．62％，대조조52．83％），혈청감성린산매하강솔（치료조70．37％，대조조45．28％）비교，차이균유통계학의의（ P＜0．05）。결론복방고삼주사액연합파미련산이납치료악성종류골전이동통료효긍정。
Objective To study the clinical efficacy of the Composite Matrine Injections combined with pamidronate disodium in the treatment of metastatic bone tumor .Methods A total of 107 patients with metastatic tumor of bone were randomly divided into the treatment and the control groups .The treatment group (n=54) were given the Composite Matrine Injections combined with pamidronate disodium and the control group (n=53) were given pamidronate disodium treatment alone .After 2 cycles of the treat‐ment ,analgesic efficacy ,adverse effects and changes of serum alkaline phosphatase were observed .Results With regard to pain re‐lief efficiency (treatment group 79 .62% ,control group 52 .83% ) ,and serum alkaline phosphatase decrease rate (treatment group 70 .37% ,control group 45 .28% ) ,a statistically significant difference was observed (P<0 .05) .Conclusion The Composite Ma‐trine Injections combined with pamidronate disodium in the treatment of metastatic bone tumor is more satisfactory than pamidr‐onate disodium alone .