CAJ | 학술논문

目的估算我国人群胃癌辐射致癌危险系数.方法应用美国电离辐射效应委员会研发的日本原子弹爆炸幸存者胃癌辐射致癌危险模型,估算其辐射致癌超额相对危险和绝对危险系数.综合日本人群辐射致癌危险转移为美国人群危险的多种转移方法,确定由日本人群向我国人群危险转移模型为相乘相加混合模型(算数尺度下,相乘和相加模型权重分别为0.7和0.3).根据我国肿瘤登记年报胃癌基线发病率,利用曲线拟合方法,估算其性别-年龄别基线发病率.综合日本人群胃癌辐射致癌危险系数及我国人群胃癌基线发病率,结合适用于我国人群的危险转移方法,估算我国人群胃癌辐射致癌危险系数.结果估算获得我国人群胃癌辐射致癌超额相对危险系数值,男性为0.26/Sv,女性为0.64/Sv(30岁受照,60岁患癌).受照年龄越小,患癌年龄越小此系数越大.结论我国人群胃癌辐射致癌危险系数高于日本原子弹爆炸幸存者,二者随性别-年龄变化趋势相同.
목적 고산아국인군위암복사치암위험계수.방법 응용미국전리복사효응위원회연발적일본원자탄폭작행존자위암복사치암위험모형,고산기복사치암초액상대위험화절대위험계수.종합일본인군복사치암위험전이위미국인군위험적다충전이방법,학정유일본인군향아국인군위험전이모형위상승상가혼합모형(산수척도하,상승화상가모형권중분별위0.7화0.3).근거아국종류등기년보위암기선발병솔,이용곡선의합방법,고산기성별-년령별기선발병솔.종합일본인군위암복사치암위험계수급아국인군위암기선발병솔,결합괄용우아국인군적위험전이방법,고산아국인군위암복사치암위험계수.결과 고산획득아국인군위암복사치암초액상대위험계수치,남성위0.26/Sv,녀성위0.64/Sv(30세수조,60세환암).수조년령월소,환암년령월소차계수월대.결론 아국인군위암복사치암위험계수고우일본원자탄폭작행존자,이자수성별-년령변화추세상동.
Objective To estimate the excess relative risk coefficients of stomach cancer for Chinese population attributable to ionizing radiation.Methods The excess relative risk and excess absolute risk coefficients of stomach cancer were estimated based on Life Span Study by using risk models developed by BEIR Ⅶ committee (Biological Effect of Ionizing Radiation).Guided by transportation methods from Life Span Study to Americans,we determined that transportation method for Chinese population includes both multiplicative and additive models with a weight of 0.7 and 0.3 respectively,on an arithmetic scale.Besides,curve fitting was used to obtain sex-age-specific stomach cancer baseline incidence based on Chinese cancer annual report.Then,Chinese excess relative risk coefficients of stomach cancer were obtained by substituting excess relative risk,excess absolute risk of Life Span Study and Chinese baseline incidence rate into risk transportation model.Results Excess relative risk coefficients of stomach cancer for Chinese population are 0.26/Sv for male and 0.64/Sv for female,whose exposure age is 30 years old and cancer age is 60 years old.Coefficients increase with decreased exposure age and cancer age.Conclusions Excess relative risk coefficients of stomach cancer for Chinese population are by larger higher than that of Life Span Study,and their sex-age tendency are similar.