CAJ | 학술논문

目的：探讨绝经后冠心病妇女血浆雌二醇与左心室重构及N末端脑钠尿肽前体（ NT-proBNP）水平的关系。方法选择绝经期女性90例，其中冠心病组50例，非冠心病对照组40例，收集年龄、血压、体表面积、体重指数等基本信息，均检测血浆雌二醇、NT-proBNP 水平，测定左心室舒张末期内径、左心室质量指数。结果冠心病组与对照组年龄、血压水平、体表面积、体重指数比较均无统计学差异（ P＞0.05）。冠心病组与对照组相比，血浆雌二醇显著降低，NT-proBNP、左心室舒张末期内径、左心室质量指数显著增加（ P＜0.05）。 Pearson直线相关分析表明，冠心病组血浆雌二醇与NT-proBNP（r＝－0.565，P＜0.05）、左心室舒张末期径（r＝－0.731，P＜0.05）、左心室质量指数（r＝－0.768，P＜0.05）呈显著负相关。结论绝经后冠心病患者血浆雌二醇水平下降，但NT-proBNP、左心室舒张末期内径、左心室质量指数增加；雌二醇水平与 NT-proBNP、左心室舒张末期内径、左心室质量指数呈负相关。
목적：탐토절경후관심병부녀혈장자이순여좌심실중구급N말단뇌납뇨태전체（ NT-proBNP）수평적관계。방법선택절경기녀성90례，기중관심병조50례，비관심병대조조40례，수집년령、혈압、체표면적、체중지수등기본신식，균검측혈장자이순、NT-proBNP 수평，측정좌심실서장말기내경、좌심실질량지수。결과관심병조여대조조년령、혈압수평、체표면적、체중지수비교균무통계학차이（ P＞0.05）。관심병조여대조조상비，혈장자이순현저강저，NT-proBNP、좌심실서장말기내경、좌심실질량지수현저증가（ P＜0.05）。 Pearson직선상관분석표명，관심병조혈장자이순여NT-proBNP（r＝－0.565，P＜0.05）、좌심실서장말기경（r＝－0.731，P＜0.05）、좌심실질량지수（r＝－0.768，P＜0.05）정현저부상관。결론절경후관심병환자혈장자이순수평하강，단NT-proBNP、좌심실서장말기내경、좌심실질량지수증가；자이순수평여 NT-proBNP、좌심실서장말기내경、좌심실질량지수정부상관。
Objective To investigate the relationships of estradiol with NT-proBNP, left ventricular end diastolic diameter (LVEDd) and left ventricular mass index(LVMI) in postmenopausal women with coronary heart disease (CHD).Methods 50 CHD patients and 40 control subjects were selected from Nanfang Hospital .The levels of estradiol and NT-proBNP were examined .So were levels of LVEDd and LVMI.Basic clinical data were evaluated,including age,hypertension,body surface area(BSA),and body mass index(BMI).Results Compared with those of control subjects,NT-proBNP,LVEDd,LVMI were elevated and estradiol was decreased (P<0.05) in CHD group. There was not significant difference in age ,hypertension,BSA,BMI between two groups.There was negative correlation between NT-proBNP, LVEDd,LVMI and estradiol.Conclusions Postmenopausal women with CHD have lower level of estradiol ,which appears to be associated with greater left ventricular remodeling and higher level of NT-proBNP.