CAJ | 학술논문

目的：探讨乙型肝炎病毒（ HBV）感染与弥漫大 B 细胞淋巴瘤（ DLBCL）临床、病理及预后的关系。方法采用酶联免疫吸附试验（ ELISA）检测2004年1月至2013年1月该院收治的150例DLBCL患者的乙肝5项和肝功能，并选取同期住院的其他肿瘤患者150例及门诊健康体检者150例作为对照。结果 DLBCL患者乙型肝炎表面抗原（HBsAg）的阳性率（22.7％）显著高于其他肿瘤组患者（9.3％）和健康对照组（8.0％）（P＜0.05）。 HBsAg阳性组及HBsAg阴性组DLBCL临床分期、肝脾受累、乳酸脱氢酶（LDH）含量、结节外受累区域和国际预后指数评分（IPI）差异具有统计学意义（P＜0.05），且二组患者化疗前后肝功能损伤情况比较亦有统计学差异（P＜0.05）。 HBsAg阴性组治疗完全缓解率及生存期均显著高于HBsAg阳性组（ P＜0.05）。结论 DLBCL患者HBsAg阳性率显著高于其他恶性肿瘤患者及健康对照，且 HBV感染与 DLBCL患者临床病理特征及预后相关。
목적：탐토을형간염병독（ HBV）감염여미만대 B 세포림파류（ DLBCL）림상、병리급예후적관계。방법채용매련면역흡부시험（ ELISA）검측2004년1월지2013년1월해원수치적150례DLBCL환자적을간5항화간공능，병선취동기주원적기타종류환자150례급문진건강체검자150례작위대조。결과 DLBCL환자을형간염표면항원（HBsAg）적양성솔（22.7％）현저고우기타종류조환자（9.3％）화건강대조조（8.0％）（P＜0.05）。 HBsAg양성조급HBsAg음성조DLBCL림상분기、간비수루、유산탈경매（LDH）함량、결절외수루구역화국제예후지수평분（IPI）차이구유통계학의의（P＜0.05），차이조환자화료전후간공능손상정황비교역유통계학차이（P＜0.05）。 HBsAg음성조치료완전완해솔급생존기균현저고우HBsAg양성조（ P＜0.05）。결론 DLBCL환자HBsAg양성솔현저고우기타악성종류환자급건강대조，차 HBV감염여 DLBCL환자림상병리특정급예후상관。
Objective To explore the relevance of hepatitis B virus ( HBV) infection to clinic pathological characteristics and prog-nosis of diffuse large-B-cell lymphoma (DLBCL).Methods The serum marker of HBV and liver function were detected by enzyme linked immunosorbent assay (ELISA) in 150 DLBCL patients, and 156 other cancer patients and healthy control .Results The positive rate of hep-atitis B virus surface antigen (HBsAg) was significantly higher in DLBCL patients (22.7%) than that in other cancer patients (9.3%) and healthy controls (8.0%) (P<0.05).Compared of clinic pathological characteristics of DLBCL patients between HBsAg positive group and HBsAg negative group showed that , the clinical stage , hepatic and splenic involvement station , concentration of lactic dehydrogenase (LDH), affected areas outside the nodules, international prognostic index (IPI) had significant differences(P<0.05), and the injury of liv-er function before and after chemotherapy also had significant differences (P<0.05).After therapy, the complete remission (CR) popula-tion in HBsAg negative group was significantly higher than that of HBsAg positive group (P<0.05).Conclusions HBsAg positive rate in DLBCL patients is significantly higher than that in other cancer patients and healthy control , and HBV infection is associated with clinic path-ological characteristics and prognosis of DLBCL .