CAJ | 학술논문

目的：探讨乳腺纤维瘤病样化生性癌的临床病理学特点及免疫组化特征。方法收集并分析1例纤维瘤病样化生性癌病例的临床特征及病理资料,进行 HE染色和免疫组化标记,并复习文献。结果组织学乳腺纤维瘤病样化生性癌大部分区域为温和的梭形细胞,仅于靠近导管区域细胞密集,并伴轻-中度异型,可见假血管瘤样、黏液样间质,并见胶原化,肿瘤周边可见乳腺增生性病变；免疫组化标记,梭形细胞既表达上皮标记 CK(AE1/AE3)、CKH(34βE12)和 CK7,,也表达肌上皮的相关标记CK5/6、p63、CD10,而ER、PR、HER-2、SMA、desmin、CD34、CD117和S-100均阴性。随访13个月,尚未发现复发或转移。结论乳腺纤维瘤病样化生性癌是乳腺化生性癌的一种亚型,诊断时需结合组织学特点及免疫标记表达情况,注意与乳腺相关的梭形细胞病变相鉴别。
목적：탐토유선섬유류병양화생성암적림상병이학특점급면역조화특정。방법수집병분석1례섬유류병양화생성암병례적림상특정급병리자료,진행 HE염색화면역조화표기,병복습문헌。결과조직학유선섬유류병양화생성암대부분구역위온화적사형세포,부우고근도관구역세포밀집,병반경-중도이형,가견가혈관류양、점액양간질,병견효원화,종류주변가견유선증생성병변；면역조화표기,사형세포기표체상피표기 CK(AE1/AE3)、CKH(34βE12)화 CK7,,야표체기상피적상관표기CK5/6、p63、CD10,이ER、PR、HER-2、SMA、desmin、CD34、CD117화S-100균음성。수방13개월,상미발현복발혹전이。결론유선섬유류병양화생성암시유선화생성암적일충아형,진단시수결합조직학특점급면역표기표체정황,주의여유선상관적사형세포병변상감별。
Obj ective To investigate the clinicopathological and immunohistochemical features of fi-bromatosis-like metaplastic carcinoma of the breast.Methods A case of fibromatosis-like metaplastic carci-noma of the breast was collected and studied by haematoxylin-eosin staining and immunohistochemistry. Clinicopathological characteristics were observed and analyzed with literature review.Results Histopatho-logically,the tumor showed a proliferation of bland spindle cells,and abundant spindle cells were only ob-served in the regions near the duct cells,with low-grade to intermediate-grade atypia.The tumor stoma showed pseudoangiomatous,myxoid or collagen elements,and the tumor surrounded by breast hyperplas-tic lesions.Immunohistochemically,the tumor cells were positive for CK(AE1/AE3),CKH(34βE12), CK7,CK5/6,p63,CD10,and negative for ER、PR,HER-2,SMA,desmin,CD34,CD117,and S-100. After ten months of follow-up,we found no evidence of recurrence or metastasis.Conclusion Fibromato-sis-like metaplastic carcinoma of the breast is a subtype of metaplastic carcinoma.The diagnosis should combine histological morphology and immunohistochemical phenotype,and should be differentiated from other spindle cell lesions of the breast.