CAJ | 학술논문

目的：通过研究1型糖尿病儿童肾叶间动脉血流动力学指标参数的变化，探讨彩色多普勒超声检查对糖尿病肾病潜伏期的临床应用价值。资料与方法选取1型糖尿病儿童52例及健康对照组51例进行肾脏彩色多普勒超声检查，测量肾叶间动脉的阻力指数（RI），并对其临床资料及实验室指标进行比较。结果糖尿病组左肾 RI、右肾 RI 及双肾平均 RI 均较对照组明显增高，差异有统计学意义（P<0.01）。糖尿病组平均 RI 与糖化血红蛋白呈正相关（r=0.96，P<0.01），与糖尿病持续时间亦呈正相关（r=0.31，P<0.01）。糖尿病组空腹血糖、糖化血红蛋白、肾小球滤过率均明显高于对照组，差异有统计学意义（P<0.01）。结论1型糖尿病患儿肾叶间动脉 RI 指数增高，彩色多普勒超声检查能提示肾脏血流动力学改变情况，对早期糖尿病肾病诊断具有一定的价值。
목적：통과연구1형당뇨병인동신협간동맥혈류동역학지표삼수적변화，탐토채색다보륵초성검사대당뇨병신병잠복기적림상응용개치。자료여방법선취1형당뇨병인동52례급건강대조조51례진행신장채색다보륵초성검사，측량신협간동맥적조력지수（RI），병대기림상자료급실험실지표진행비교。결과당뇨병조좌신 RI、우신 RI 급쌍신평균 RI 균교대조조명현증고，차이유통계학의의（P<0.01）。당뇨병조평균 RI 여당화혈홍단백정정상관（r=0.96，P<0.01），여당뇨병지속시간역정정상관（r=0.31，P<0.01）。당뇨병조공복혈당、당화혈홍단백、신소구려과솔균명현고우대조조，차이유통계학의의（P<0.01）。결론1형당뇨병환인신협간동맥 RI 지수증고，채색다보륵초성검사능제시신장혈류동역학개변정황，대조기당뇨병신병진단구유일정적개치。
Purpose To study the hemodynamic changes of kidney interlobar artery in children with type 1 diabetes, and to explore the clinical value of the color Doppler ultrasound in diabetic nephropathy during the incubation period. Materials and Methods The study was performed in 52 children with type 1 diabetes and in 51 age-matched healthy children as control group. The resistance index (RI) of interlobar artery was measured with color Doppler ultrasonography, and the clinical data and laboratory indicators were analyzed. Results The left kidney RI, right kidney RI and average RI were all significantly higher in children with diabetes than in age-matched healthy group (P<0.01). The mean RI were correlated positively with (HbA1c) (r=0.96, P<0.01) and diabetes duration (r=0.31, P<0.01), respectively. Fasting blood glucose, glycated hemoglobin, and glomerular filtration rate were significantly higher in children with diabetes than in age-matched healthy group (P<0.01). Conclusion The RI of interlobar artery increases in children with type 1 diabetes. Early changes of renal hemodynamics in children with type 1 diabetes are detectable with Doppler sonography, and have certain value in early diagnosis of diabetic nephropathy.