CAJ | 학술논문

人巨细胞病毒（HCMV）是一个广泛传播的机会致病原，也是不断利用和操控机体免疫系统致慢性持续性病毒感染的典型代表。在病毒与宿主共同漫长进化过程中，HCMV产生了许多逃避宿主免疫系统识别的机制，其基因组编码了大量产物，通过抑制自然杀伤细胞和树突细胞功能，下调被感染细胞表面主要组织相容性复合体（MHC）Ⅰ类和Ⅱ类分子表达以减少病毒抗原呈递，损伤IgG介导的体液免疫，调节多种趋化因子和细胞因子的作用，从而控制宿主天然免疫应答和适应性免疫应答的核心功能。本文就HCMV的免疫逃避机制进行综述，探讨病毒与宿主相互作用的发生、发展与结局。
인거세포병독（HCMV）시일개엄범전파적궤회치병원，야시불단이용화조공궤체면역계통치만성지속성병독감염적전형대표。재병독여숙주공동만장진화과정중，HCMV산생료허다도피숙주면역계통식별적궤제，기기인조편마료대양산물，통과억제자연살상세포화수돌세포공능，하조피감염세포표면주요조직상용성복합체（MHC）Ⅰ류화Ⅱ류분자표체이감소병독항원정체，손상IgG개도적체액면역，조절다충추화인자화세포인자적작용，종이공제숙주천연면역응답화괄응성면역응답적핵심공능。본문취HCMV적면역도피궤제진행종술，탐토병독여숙주상호작용적발생、발전여결국。
Human cytomegalovirus (HCMV ) is a widespread opportunistic pathogen , causing chronic and persistent infections by controlling body’s immune system .During the long evolution process of the virus and the host , the virus has developed mechanisms to evade the host immune system . The viral genome encodes a large number of products to control the central functions of both innate and adaptive immunity of the host by inhibiting the functions of natural killer (NK ) cells and dendritic cells , down‐regulating the expressions of major histocompatibility complex (MHC ) class I and II in infected cells , impairing IgG‐mediated humoral immunity as well as regulating the functions of chemokines and cytokines . This paper reviews the immune interfering mechanisms by HCMV ,and probes into the occurrence ,development and outcomes of the interaction between the virus and the host .