中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2015年
4期
273-275
,共3页
肺疾病,慢性阻塞性%氨基末端脑钠肽前体%D-二聚体
肺疾病,慢性阻塞性%氨基末耑腦鈉肽前體%D-二聚體
폐질병,만성조새성%안기말단뇌납태전체%D-이취체
Pulmonary disease,chronic obstructive%N-terminal pro-brain natriuretic peptide%D-dimer
目的 探讨血清氨基末端脑钠肽前体(NT-proBNP)和血浆D-二聚体(D-D)在慢性阻塞性肺疾病急性加重期(AECOPD)和稳定期患者中的水平变化,并分析其临床意义.方法 对76例AECOPD患者(AECOPD组)及68例稳定期COPD患者(稳定期COPD组)的临床资料进行回顾性分析.所有患者均进行血清NT-proBNP和血浆D-D检测及动脉血气分析.结果 AECOPD组血清NT-pro BNP及血浆D-D水平显著高于稳定期COPD组[(918 ±271) ng/L比(264±32) ng/L,(0.269±0.048) mg/L比(0.223±0.042) mg/L],差异有统计学意义(P＜0.01).血清NT-proBNP和血浆D-D水平与动脉血氧分压呈负相关(r=-0.181,P=0.030;r=-0.166,P=0.047),与动脉血二氧化碳分压呈正相关(r=0.763,P＜0.01;r=0.424,P＜0.01).结论 联合检测血清NT-proBNP和血浆D-D水平变化对评估COPD的病情变化有重要的临床意义,可以提示COPD急性加重.
目的 探討血清氨基末耑腦鈉肽前體(NT-proBNP)和血漿D-二聚體(D-D)在慢性阻塞性肺疾病急性加重期(AECOPD)和穩定期患者中的水平變化,併分析其臨床意義.方法 對76例AECOPD患者(AECOPD組)及68例穩定期COPD患者(穩定期COPD組)的臨床資料進行迴顧性分析.所有患者均進行血清NT-proBNP和血漿D-D檢測及動脈血氣分析.結果 AECOPD組血清NT-pro BNP及血漿D-D水平顯著高于穩定期COPD組[(918 ±271) ng/L比(264±32) ng/L,(0.269±0.048) mg/L比(0.223±0.042) mg/L],差異有統計學意義(P＜0.01).血清NT-proBNP和血漿D-D水平與動脈血氧分壓呈負相關(r=-0.181,P=0.030;r=-0.166,P=0.047),與動脈血二氧化碳分壓呈正相關(r=0.763,P＜0.01;r=0.424,P＜0.01).結論 聯閤檢測血清NT-proBNP和血漿D-D水平變化對評估COPD的病情變化有重要的臨床意義,可以提示COPD急性加重.
목적 탐토혈청안기말단뇌납태전체(NT-proBNP)화혈장D-이취체(D-D)재만성조새성폐질병급성가중기(AECOPD)화은정기환자중적수평변화,병분석기림상의의.방법 대76례AECOPD환자(AECOPD조)급68례은정기COPD환자(은정기COPD조)적림상자료진행회고성분석.소유환자균진행혈청NT-proBNP화혈장D-D검측급동맥혈기분석.결과 AECOPD조혈청NT-pro BNP급혈장D-D수평현저고우은정기COPD조[(918 ±271) ng/L비(264±32) ng/L,(0.269±0.048) mg/L비(0.223±0.042) mg/L],차이유통계학의의(P＜0.01).혈청NT-proBNP화혈장D-D수평여동맥혈양분압정부상관(r=-0.181,P=0.030;r=-0.166,P=0.047),여동맥혈이양화탄분압정정상관(r=0.763,P＜0.01;r=0.424,P＜0.01).결론 연합검측혈청NT-proBNP화혈장D-D수평변화대평고COPD적병정변화유중요적림상의의,가이제시COPD급성가중.
Objective To explore the clinical significance of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and plasma D-dimer (D-D) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and stable chronic obstructive pulmonary disease (COPD).Methods The clinical data of 76 patients with AECOPD (AECOPD group) and 68 patients with stable COPD (stable COPD group) were analyzed retrospectively.Serum NT-proBNP,plasma D-D levels and arterial blood gas analysis were measured and compared.Results The levels of serum NT-proBNP and plasma D-D in AECOPD group were (918 ± 271) ng/L and (0.269 ±0.048) mg/L,in stable COPD group were (264 ± 32) ng/L and (0.223 ± 0.042) mg/L.The levels of serum NT-proBNP and plasma D-D in AECOPD group were significantly higher than those in stable COPD group (P ＜ 0.01).The levels of serum NT-proBNP and plasma D-D were negatively correlated with arterial blood oxygen partial pressure (r =-0.181,P =0.030;r =-0.166,P =0.047),and were positively correlated with arterial blood carbon dioxide partial pressure (r =0.763,P ＜ 0.01;r =0.424,P ＜ 0.01).Conclusion Combined detection of serum NT-proBNP and plasma D-D has important clinical significance in evaluating severity of COPD,and may indicate AECOPD.
