CAJ | 학술논문

采用逆相蒸发法制备甘草酸二铵脂质体，通过均匀设计法优化脂质体处方及制备工艺，利用透射电镜观察其形态，通过HPLC测定脂质体包封率。所制得的甘草酸二铵脂质体形态呈球形，大小较均匀，粒径范围在50～100 nm，包封率36．47％，稳定性佳。
채용역상증발법제비감초산이안지질체，통과균균설계법우화지질체처방급제비공예，이용투사전경관찰기형태，통과HPLC측정지질체포봉솔。소제득적감초산이안지질체형태정구형，대소교균균，립경범위재50～100 nm，포봉솔36．47％，은정성가。
Diammonium glycyrrhizinate liposome was prepared by the reverse evaporating method .The li-posome was prepared by homogeneous design .The shape of liposome was observed under the electronic microscope .The shape and size distribution was detected by transmission electrical microscope .The mean entrapment efficiency was detected with HPLC .The shape of diammonium glycyrrhizinate liposome was spherical and regular in its morphology and the diameter ranges of the liposome were 50~100 nm. The entrapment efficiency of the liposome was 36 .47%and the stability of the liposome was good .