潍坊医学院学报
濰坊醫學院學報
유방의학원학보
JOURNAL OF WEIFANG MEDICAL COLLEGE
2015年
2期
100-101
,共2页
康柏西普%湿性老年性黄斑变性%玻璃体腔注射
康柏西普%濕性老年性黃斑變性%玻璃體腔註射
강백서보%습성노년성황반변성%파리체강주사
Conbercept%Wet age-related macular degeneration%Intravitreal injection
目的：观察湿性老年性黄斑变性行玻璃体腔注射康柏西普后的疗效。方法将确诊为湿性老年性黄斑变性的患者30例（38眼）给予康柏西普0．5mg（0．05ml）玻璃体腔注射，观察术前、术后1周、2周、1个月的最佳矫正ETDRS视力及黄斑区视网膜中心厚度。结果术后1周、2周及1个月最佳矫正ETDRS视力分别为（45．34±10．75），（49．06±11．28），（52．09±11．92）个字母，均较术前（35．06±13．67）个字母有提高，差异有统计学意义（均P＜0．05）；术后1周、2周及1个月黄斑区视网膜中心厚度分别为（382．83±90．67）μm，（367．23±63．73）μm，（326．22±58．74）μm，均较术前（480．63±92．97）μm变薄，差异有统计学意义（均P＜0．05）。治疗期间未发生严重并发症。结论玻璃体腔注射康柏西普后可减轻湿性老年性黄斑变性患者的黄斑水肿，提高患者视力。
目的：觀察濕性老年性黃斑變性行玻璃體腔註射康柏西普後的療效。方法將確診為濕性老年性黃斑變性的患者30例（38眼）給予康柏西普0．5mg（0．05ml）玻璃體腔註射，觀察術前、術後1週、2週、1箇月的最佳矯正ETDRS視力及黃斑區視網膜中心厚度。結果術後1週、2週及1箇月最佳矯正ETDRS視力分彆為（45．34±10．75），（49．06±11．28），（52．09±11．92）箇字母，均較術前（35．06±13．67）箇字母有提高，差異有統計學意義（均P＜0．05）；術後1週、2週及1箇月黃斑區視網膜中心厚度分彆為（382．83±90．67）μm，（367．23±63．73）μm，（326．22±58．74）μm，均較術前（480．63±92．97）μm變薄，差異有統計學意義（均P＜0．05）。治療期間未髮生嚴重併髮癥。結論玻璃體腔註射康柏西普後可減輕濕性老年性黃斑變性患者的黃斑水腫，提高患者視力。
목적：관찰습성노년성황반변성행파리체강주사강백서보후적료효。방법장학진위습성노년성황반변성적환자30례（38안）급여강백서보0．5mg（0．05ml）파리체강주사，관찰술전、술후1주、2주、1개월적최가교정ETDRS시력급황반구시망막중심후도。결과술후1주、2주급1개월최가교정ETDRS시력분별위（45．34±10．75），（49．06±11．28），（52．09±11．92）개자모，균교술전（35．06±13．67）개자모유제고，차이유통계학의의（균P＜0．05）；술후1주、2주급1개월황반구시망막중심후도분별위（382．83±90．67）μm，（367．23±63．73）μm，（326．22±58．74）μm，균교술전（480．63±92．97）μm변박，차이유통계학의의（균P＜0．05）。치료기간미발생엄중병발증。결론파리체강주사강백서보후가감경습성노년성황반변성환자적황반수종，제고환자시력。
Objective To observe the efficacy of Conbercept intravitreal injection treatment on wet age -related macular degenera-tion.Methods Thirty cases patients(38 eyes)diagnosed with age-related macular degeneration were seclected and injected Conbercep 0.5mg (0.05ml) intravitreal,and the visual acuity and the central macular thinckness of preoperative ,postoperative 1 week,postoperative two weeks and postoperative 1 month were measured with the international standard treatment of early diabetic eye chart (ETDRS).Results The best corrected ETDRS visual acuity of postoperative 1 week,after two weeks and after 1 month was 45.34 ±10.75,49.06 ±11.28,52.09 ±11.92 (number of letters),which were all higher than preoperative (35.06 ±13.67 number of letters),the differences were statistically significant (P<0.05).The central macular thinckness of postoperative 1 week,postoperative two weeks and postoperative 1 month was 382.83μm ±90. 67μm,367.23μm ±63.73μm,326.22μm ±58.74μm,which were thinner than preoperative (480.63μm ±92.97μm),the differences were statistically significant(P<0.05),too.No serious complications occurred during treatment .Conclusion Conbercep intravitreal can reduce the macular edema of patients with wet age-related macular degeneration and improve visual acuity .
