CAJ | 학술논문

目的：通过对慢性乙型肝炎（ CHB ）患者血脂相关指标水平的检测来研究其对肝脏损伤程度的判断。方法随机选取单纯CHB患者40例，乙型肝炎后肝硬化患者30例，40例健康对照者（ HC ）作为研究对象，检测入选研究对象血脂相关指标：甘油三酯（ TG ）、总胆固醇（ CHO ）、高密度脂蛋白胆固醇（ HDL－C ）、载脂蛋白A1（ApoA1）、载脂蛋白B100（ApoB100），肝功相关指标：谷丙转氨酶（ALT）、总胆红素（TBiL）。根据检测结果，回顾性分析血脂各项指标与谷丙转氨酶、总胆红素之间的相关性，探讨血脂指标反映肝脏损害程度。结果单纯慢乙肝、乙型肝炎肝硬化患者的血脂相关指标水平较健康对照者明显降低（P均＜0．05），分析患病研究对象血清CHO，TG，HDL－C，ApoA1，ApoB100与血清ALT，TBiL，发现血脂指标与肝功指标有显著的负相关性（P＜0．05）。结论慢乙肝患者血脂相关指标水平明显低于健康人群并能反映肝细胞损害程度，加强慢乙肝患者血清TG，CHO等血脂相关指标的随访检测是有必要的。
목적：통과대만성을형간염（ CHB ）환자혈지상관지표수평적검측래연구기대간장손상정도적판단。방법수궤선취단순CHB환자40례，을형간염후간경화환자30례，40례건강대조자（ HC ）작위연구대상，검측입선연구대상혈지상관지표：감유삼지（ TG ）、총담고순（ CHO ）、고밀도지단백담고순（ HDL－C ）、재지단백A1（ApoA1）、재지단백B100（ApoB100），간공상관지표：곡병전안매（ALT）、총담홍소（TBiL）。근거검측결과，회고성분석혈지각항지표여곡병전안매、총담홍소지간적상관성，탐토혈지지표반영간장손해정도。결과단순만을간、을형간염간경화환자적혈지상관지표수평교건강대조자명현강저（P균＜0．05），분석환병연구대상혈청CHO，TG，HDL－C，ApoA1，ApoB100여혈청ALT，TBiL，발현혈지지표여간공지표유현저적부상관성（P＜0．05）。결론만을간환자혈지상관지표수평명현저우건강인군병능반영간세포손해정도，가강만을간환자혈청TG，CHO등혈지상관지표적수방검측시유필요적。
Objective To study the judgment of the degree of liver injury through detecting the blood lipid related indexes of chronic hepatitis B (CHB) pations.Methods Randomly selecting 40 patients with pure CHB,30 pa-tients with liver cirrhosis after hepatitis B ,and 40 cases of healthy controls ( HC) as the object of study .Then detecting blood lipid related indexes:triglyceride(TG),total cholesterol(CHO),high density lipoprotein(HDL-C),apolipoprotein A1(ApoA1),apolipoprotein B100(ApoB100) and relevant indicators of liver function:alanine aminotransferase(ALT),to-tal bilirubin(TBiL).According to the detecting results,a retrospective analysis of the correlation between blood lipid in-dexes,glutamic pyruvic transaminase and total bilirubin were made and the relationship between blood lipid index and the degree of liver injury were explored .Results The blood lipid levels of both pure chronic hepatitis B and cirrhosis of hepatitis B patients were significantly different , they were all higher than the blood lipid levels of the healthy control group(P<0.05).Then the analyzation of the relevance between serum CHO ,TG,HDL-C,ApoA1,ApoB100 and serum ALT,TBiL of pations infected HBV showed a significant negative correlation between them (P<0.05).Conclusion Blood lipid related indexes of chronic hepatitis B patients are significantly lower than that in healthy people and can re -flect the damage degree of liver .It's necessary to detect and follow-up the blood lipid related indexes including TG ,CHO of CHB patients .