CAJ | 학술논문

目的：探讨Jagged1和Hes1在食管癌中的表达和临床意义。方法应用免疫组织化学PV－9000法检测52例食管癌组织和20例癌旁正常组织中Jagged1和Hes1的表达水平，分析其与食管癌各临床病理因素之间的相关性及临床意义。结果 Jagged1和Hes1在食管癌组织中的阳性表达率均显著低于癌旁正常组织，差异有统计学意义（P＜0．05）。 Hes1的表达与食管癌的淋巴结转移、临床分期、分化程度、侵袭程度密切相关（P＜0．05）。 Jagged1的表达与食管癌的分化程度、侵袭深度及淋巴结有无转移密切相关。食管癌组织中Hes1和Jag－ged11两者的表达呈正相关（ P＜0．05）。结论 Hes1和Jagged1的异常表达与食管癌的发生、浸润及转移密切相关，检测两种蛋白对于食管癌的早期诊断及预后具有一定的参考价值。
목적：탐토Jagged1화Hes1재식관암중적표체화림상의의。방법응용면역조직화학PV－9000법검측52례식관암조직화20례암방정상조직중Jagged1화Hes1적표체수평，분석기여식관암각림상병리인소지간적상관성급림상의의。결과 Jagged1화Hes1재식관암조직중적양성표체솔균현저저우암방정상조직，차이유통계학의의（P＜0．05）。 Hes1적표체여식관암적림파결전이、림상분기、분화정도、침습정도밀절상관（P＜0．05）。 Jagged1적표체여식관암적분화정도、침습심도급림파결유무전이밀절상관。식관암조직중Hes1화Jag－ged11량자적표체정정상관（ P＜0．05）。결론 Hes1화Jagged1적이상표체여식관암적발생、침윤급전이밀절상관，검측량충단백대우식관암적조기진단급예후구유일정적삼고개치。
Objective To investigate the expression and clinical significance of Jagged 1 and Hes1 in esoph-ageal cancer .Methods Immunohistochemical PV-9000 was used to test the expression levels of Jagged 1 of 52 cases Hes1 esophageal cancer tissues and 20 cases normal tissues and analyze their correlation and clinical significance be-tween esophageal cancer and clinicopathological factors .Results The expression rate of Jagged 1 and Hes1 in esophageal cancer was significantly lower than that in adjacent normal tissues ,the difference was statistically significant (P<0.05). Expression of hes1 was closely related to lymph node metastasis of esophageal cancer ,clinical stage,degree of differentia-tion and the degree of invasion ( P<0 .05 ) .So did the expression of Jagged and differentiation of esophageal cancer , depth of invasion,lymph node metastasis.The expression of Hes1 and Jagged1 in esophageal carcinoma were positively correlated(P<0.05).Conclusion Abnormal expression of Hes1 and Jagged1 is correlated with esophageal cancer's de-velopment ,invasion and metastasis .Detection of the two proteins has a certain reference value for early diagnosis and prognosis of esophageal cancer .