CAJ | 학술논문

目的：研究余甘子鞣质部位对荷肉瘤 S180和肝癌 H22移植瘤小鼠的肿瘤抑制作用及免疫器官的影响。方法将72只 SPF 级的 ICR 小鼠分为6组，分别为空白对照组、荷肉瘤 S180模型组、余甘子鞣质部位低（0.5 g·kg-1，相当于生药3.64 g·kg-1）、中（1.0 g·kg-1，相当于生药7.27 g·kg-1）、高（2.0 g·kg-1，相当于生药14.54 g·kg-1）剂量组，另设环磷酰胺组阳性药组；对荷肝癌 H22小鼠的抑瘤实验分组同上。小鼠分别连续 ig 给药10 d 及12 d 后，计算抑瘤率、胸腺指数和脾脏指数。结果余甘子鞣质部位低、中、高剂量组对荷肉瘤 S180移植瘤小鼠组的抑瘤率分别为16.52%、40.08%（P <0.05）、56.19%（P <0.01），对荷肝癌 H22移植瘤小鼠组的抑瘤率分别为18.36%、34.01%（P <0.05)、51.02%（P <0.01）。与模型组相比，余甘子鞣质部位低、中、高剂量组小鼠的胸腺指数和脾脏指数均无显著性差异（P >0.05）。结论灌胃给予余甘子鞣质部位对两种荷瘤小鼠的肿瘤生长均有明显的抑制作用，且呈一定剂量依赖性，对荷瘤小鼠免疫器官未见明显影响。
목적：연구여감자유질부위대하육류 S180화간암 H22이식류소서적종류억제작용급면역기관적영향。방법장72지 SPF 급적 ICR 소서분위6조，분별위공백대조조、하육류 S180모형조、여감자유질부위저（0.5 g·kg-1，상당우생약3.64 g·kg-1）、중（1.0 g·kg-1，상당우생약7.27 g·kg-1）、고（2.0 g·kg-1，상당우생약14.54 g·kg-1）제량조，령설배린선알조양성약조；대하간암 H22소서적억류실험분조동상。소서분별련속 ig 급약10 d 급12 d 후，계산억류솔、흉선지수화비장지수。결과여감자유질부위저、중、고제량조대하육류 S180이식류소서조적억류솔분별위16.52%、40.08%（P <0.05）、56.19%（P <0.01），대하간암 H22이식류소서조적억류솔분별위18.36%、34.01%（P <0.05)、51.02%（P <0.01）。여모형조상비，여감자유질부위저、중、고제량조소서적흉선지수화비장지수균무현저성차이（P >0.05）。결론관위급여여감자유질부위대량충하류소서적종류생장균유명현적억제작용，차정일정제량의뢰성，대하류소서면역기관미견명현영향。
Objective To investigate the antitumor activity of tannin part of Phyllanthi fructus on S180 and H22 tumor-bearing mice. Methods The ICR mice were divided into control group, model group, tannin part of Phyllanthi fructus low (0.5 g·kg-1, the equivalent of crude drug 3.64 g·kg-1), medium (1.0 g·kg-1, the equivalent of crude drug 7.27 g·kg-1), high (2.0 g·kg-1, the equivalent of crude drug 14.54 g·kg-1) dose group, a separate cyclopho-sphamide group. After continuous intragastric administered 10 d(S180) and 12 d(H22), the tumor inhibition rate, thymus index and spleen index were calculated respectively. Results The tumor inhibition rate of low, medium and high dose groups of tannin part of Phyllanthi fructus on S180 tumor-bearing mice were 16.52%,40.08% (P<0.05),56.19%(P <0.01), on H22 tumor-bearing mice were 18.36%, 34.01% (P <0.05), 51.02% P <0.01). Compared to the model group, thymus index and spleen index of all tannin part of Phyllanthi fructus treated groups were not significantly different (P>0.05). Conclusion Intragastric administration of tannin part of Phyllanthi fructus significantly inhibited the tumor growth in the tumor-bearing mice in a dose-dependent manner. No obvious changes were detected in immune organs in the trial groups.