CAJ | 학술논문

目的：研究口服氨甲环酸联合Q开关Nd∶YAG激光治疗黄褐斑的临床疗效和安全性。方法57例黄褐斑患者随机分为试验组和对照组，试验组在接受Nd∶YAG激光治疗的同时口服氨甲环酸片12周，对照组仅接受Nd∶YAG激光治疗。治疗后4、8、12周对患者进行黄褐斑皮损面积和严重度指数（MASI）评分，观察临床治疗效果并记录不良反应。结果随着治疗时间增加，患者的MASI评分逐渐下降。治疗后8周、12周，试验组和对照组患者MASI评分比较差异有统计学意义（P＜0.05）。两组患者无明显不良反应发生。结论 Q开关Nd∶YAG激光联合氨甲环酸口服治疗黄褐斑安全有效，且不良反应少。
목적：연구구복안갑배산연합Q개관Nd∶YAG격광치료황갈반적림상료효화안전성。방법57례황갈반환자수궤분위시험조화대조조，시험조재접수Nd∶YAG격광치료적동시구복안갑배산편12주，대조조부접수Nd∶YAG격광치료。치료후4、8、12주대환자진행황갈반피손면적화엄중도지수（MASI）평분，관찰림상치료효과병기록불량반응。결과수착치료시간증가，환자적MASI평분축점하강。치료후8주、12주，시험조화대조조환자MASI평분비교차이유통계학의의（P＜0.05）。량조환자무명현불량반응발생。결론 Q개관Nd∶YAG격광연합안갑배산구복치료황갈반안전유효，차불량반응소。
ObjectiveTo evaluate the efficacy and safety of oral tranexamic acid (TA) combined with low-fluence 1064nm Q-switched Nd:YAG laser in the treatment of melasma. MethodsFifty-seven patients with melasma were enrolled in the study and randomly divided into two groups: a combination group and a laser treatment group. All the patients were treated with low-lfuence Nd:YAG laser, meanwhile TA was taken orally by the patients in the combination group lasted for 12 weeks. The degree of improvement in pigmentation was reassessed on 4, 8 and 12 weeks after treatment by melasma area severity index (MASI) scores. Side-effects, if any, were also recorded.ResultsThe MASI scores were decreased with the process of the treatment. Two groups showed signiifcant difference on 8 and 12 weeks after treatment (P<0.05). No serious adverse effects had been found.ConclusionOral TA in combination with low-lfuence Nd:YAG laser may be a safe and efifcient treatment option for melasma.