中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
5期
9-12
,共4页
2型糖尿病%胱抑素C%老年%颈动脉粥样硬化
2型糖尿病%胱抑素C%老年%頸動脈粥樣硬化
2형당뇨병%광억소C%노년%경동맥죽양경화
Type 2 diabetes mellitus%Cystatin C%Elderly%Carotid atherosclerosis
目的：探讨血清胱抑素C （Cys C）水平与老年2型糖尿病患者颈动脉粥样硬化发生、发展的关系。方法共入选143例老年2型糖尿病患者，根据颈动脉内膜中层厚度（IMT）将其分为IMT正常组（n=36）和IMT增厚组（n=107）；根据颈动脉有无狭窄，将其分为无狭窄组（n=109）和狭窄组（n=34）。检测并比较各组的空腹血糖、Cys C等指标。结果 IMT增厚组血清Cys C水平明显高于IMT正常组（P＜0.05）；颈动脉狭窄组血清Cys C水平明显高于颈动脉无狭窄组（P＜0.05）。相关分析显示，老年2型糖尿病患者颈动脉IMT增厚、颈动脉狭窄均与血清Cys C水平呈正相关。Logistic回归分析显示，高水平Cys C为颈动脉狭窄发生的危险因素（OR=7.26，95％CI：1.222～43.153，P＜0.01）。结论血清Cys C水平与老年2型糖尿病患者颈动脉粥样硬化密切相关，是老年2型糖尿病颈动脉狭窄发生的重要危险因素。
目的：探討血清胱抑素C （Cys C）水平與老年2型糖尿病患者頸動脈粥樣硬化髮生、髮展的關繫。方法共入選143例老年2型糖尿病患者，根據頸動脈內膜中層厚度（IMT）將其分為IMT正常組（n=36）和IMT增厚組（n=107）；根據頸動脈有無狹窄，將其分為無狹窄組（n=109）和狹窄組（n=34）。檢測併比較各組的空腹血糖、Cys C等指標。結果 IMT增厚組血清Cys C水平明顯高于IMT正常組（P＜0.05）；頸動脈狹窄組血清Cys C水平明顯高于頸動脈無狹窄組（P＜0.05）。相關分析顯示，老年2型糖尿病患者頸動脈IMT增厚、頸動脈狹窄均與血清Cys C水平呈正相關。Logistic迴歸分析顯示，高水平Cys C為頸動脈狹窄髮生的危險因素（OR=7.26，95％CI：1.222～43.153，P＜0.01）。結論血清Cys C水平與老年2型糖尿病患者頸動脈粥樣硬化密切相關，是老年2型糖尿病頸動脈狹窄髮生的重要危險因素。
목적：탐토혈청광억소C （Cys C）수평여노년2형당뇨병환자경동맥죽양경화발생、발전적관계。방법공입선143례노년2형당뇨병환자，근거경동맥내막중층후도（IMT）장기분위IMT정상조（n=36）화IMT증후조（n=107）；근거경동맥유무협착，장기분위무협착조（n=109）화협착조（n=34）。검측병비교각조적공복혈당、Cys C등지표。결과 IMT증후조혈청Cys C수평명현고우IMT정상조（P＜0.05）；경동맥협착조혈청Cys C수평명현고우경동맥무협착조（P＜0.05）。상관분석현시，노년2형당뇨병환자경동맥IMT증후、경동맥협착균여혈청Cys C수평정정상관。Logistic회귀분석현시，고수평Cys C위경동맥협착발생적위험인소（OR=7.26，95％CI：1.222～43.153，P＜0.01）。결론혈청Cys C수평여노년2형당뇨병환자경동맥죽양경화밀절상관，시노년2형당뇨병경동맥협착발생적중요위험인소。
ObjectiveTo study the relation between serum cystatin C (Cys C)level and the development of carotid atherosclerosis in elderly patients with type 2 diabetes.Methods One hundred and forty-three elderly patients with type 2 diabetes were also divided into normal IMT group(n=36)and thicker IMT group(n=107) according to the intima media thickness(IMT).The 143 cases were divided into non-carotid artery stenosis group(n=109) and carotid artery stenosis group(n=34).Serum 1evels of fasting blood glucose and serum Cys C level were measured.Results The average serum Cys C level in thicker IMT group was significantly higher than that innormal group (IMTP<0.05). Average level of erum Cys C in the group with carotid artery stenosis was significantly higher than that in non restenosis group(P<0.05).In patients with type 2 diabetes,carotid IMTand carotid artery stenosis were positively correlated with serum level of cystatin C. Logistic regression analysis revealed that high serum level of cystatin C was a risk factor for carotid artery stenosis (OR=7.26,95%CI:1.222~43.153,P<0.01).Conclusion Serum cystatin C level is closely related to carotid atherosclerosis in elderly patients with type 2 diabetes mellitus, and it is also a risk factor for carotid stenosis.
