CAJ | 학술논문

目的：探讨5-氨基酮戊酸光动力疗法（5-ALA-PDT）治疗面部难治性扁平疣的有效性与安全性研究。方法将符合标准的96例面部难治性扁平疣患者随机分成观察组和对照组各48例，观察组患者使用5-氨基酮戊酸光动力疗法（5-ALA-PDT），对照组患者使用传统CO2激光疗法。比较两组患者疣体数清除率、愈合质量、临床疗效以及复发率和不良反应。结果观察组疣清除率为97.89％，显著高于对照组的81.21％（P＜0.05）；两组疣体脱1个月后评价愈合质量发现，观察组愈合质量显著高于对照组（P＜0.05）；此外观察组痊愈率与总有效率分别为87.72％与97.54％，显著性高于对照组的50.34％与79.53％（P＜0.05），而不良反应发生率显著低于对照组（P＜0.05）。结论5-ALA-PDT疗法在疣体的愈合质量情况评价、减少疣体复发率及不良反应方面以及提高临床疗效均优于CO2激光疗法。
목적：탐토5-안기동무산광동력요법（5-ALA-PDT）치료면부난치성편평우적유효성여안전성연구。방법장부합표준적96례면부난치성편평우환자수궤분성관찰조화대조조각48례，관찰조환자사용5-안기동무산광동력요법（5-ALA-PDT），대조조환자사용전통CO2격광요법。비교량조환자우체수청제솔、유합질량、림상료효이급복발솔화불량반응。결과관찰조우청제솔위97.89％，현저고우대조조적81.21％（P＜0.05）；량조우체탈1개월후평개유합질량발현，관찰조유합질량현저고우대조조（P＜0.05）；차외관찰조전유솔여총유효솔분별위87.72％여97.54％，현저성고우대조조적50.34％여79.53％（P＜0.05），이불량반응발생솔현저저우대조조（P＜0.05）。결론5-ALA-PDT요법재우체적유합질량정황평개、감소우체복발솔급불량반응방면이급제고림상료효균우우CO2격광요법。
ObjectiveTo integrative safety and effectiveness of 5-aminolevulinic acid photodynamic therapy (5-ALA-PDT) in treatment of patients with recalcitrant facial flat warts.Methods 96 patients with this disease were randomly divided into observed group (48 cases) and control group (48 cases). Patients in observed group received the treatment of 5-ALA-PDT, while others received the treatment of CO2 laser therapy. The wart removal rate, quality of healing, clinical effect and recurrence rate and adverse reaction of the two groups were compared.Results The wart removal rate of 97.89% in observation group was significantly higher than that of 81.21% in the control group (P<0.05); the healing quality of observation group was significantly better than that of the control group (P<0.05); in addition, cure rate and total effective rate of observation group were 87.72% and 97.54%, which were significantly higher than those of 50.34% and 79.53% in the control group (P<0.05), while the adverse reaction rate in observation group was significantly lower than that in the control group (P<0.05).Conclusion Compared with CO2 laser therapy, the treatment of 5-ALA-PDT therapy can improve wart removal rate, quality of healing, clinical effect, reduce recurrence rate and adverse reaction. It is worthy of promotion and application.