CAJ | 학술논문

轮状病毒感染是引起儿童腹泻的主要原因。在发达国家，由轮状病毒感染导致的急诊和住院造成了巨大的经济负担，在发展中国家则是导致儿童死亡的主要原因。使用疫苗是预防轮状病毒感染的有效手段。1999年，第一代轮状病毒疫苗 RotaShield 由于怀疑能增加接种儿童罹患肠套叠风险而撤市。2006年，第二代轮状病毒疫苗 RotaTeq和 Rotarix 先后上市，第二代轮状病毒疫苗与肠套叠的关联性仍是当前关注的热点。目前各国尚无针对轮状病毒疫苗接种规程的新的举措。通过综述了有关轮状病毒疫苗和肠套叠开展的关联性研究，以期为轮状病毒疫苗的安全使用提供参考。
륜상병독감염시인기인동복사적주요원인。재발체국가，유륜상병독감염도치적급진화주원조성료거대적경제부담，재발전중국가칙시도치인동사망적주요원인。사용역묘시예방륜상병독감염적유효수단。1999년，제일대륜상병독역묘 RotaShield 유우부의능증가접충인동리환장투첩풍험이철시。2006년，제이대륜상병독역묘 RotaTeq화 Rotarix 선후상시，제이대륜상병독역묘여장투첩적관련성잉시당전관주적열점。목전각국상무침대륜상병독역묘접충규정적신적거조。통과종술료유관륜상병독역묘화장투첩개전적관련성연구，이기위륜상병독역묘적안전사용제공삼고。
Rotavirus is the main cause of diarrheal illness among children. In developed countries, it's a huge financial burden of emergency and hospitalization due to rotavirus infection. In developing countries, it's the main reason to children death. Vaccination is one of the effective methods to prevent the disease. The first vaccine, RotaShield, was withdrawn from the market in 1999 because it was suspected to increase the risk of intussusception in recipients. In 2006, the new vaccine, RotaTeq and Rotarix, were introduced to the market. The relationship between rotavirus vaccine and intussusception is still the hot topic. There are still no changes of immunization program about rotavirus vaccine in the world.In the paper, the researches about rotavirus vaccine and intussusception are summarized.