中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2015年
4期
324-327
,共4页
2型糖尿病%血糖波动%动态血糖监测%颈动脉内膜-中膜厚度%粥样硬化斑块
2型糖尿病%血糖波動%動態血糖鑑測%頸動脈內膜-中膜厚度%粥樣硬化斑塊
2형당뇨병%혈당파동%동태혈당감측%경동맥내막-중막후도%죽양경화반괴
Type 2 diabetes(T2DM)%Blood glucose fluctuation%Dynamic blood sugar monitoring%Carotid intima -media thickness%Atherosclerotic plaques
目的:探讨2型糖尿病患者颈动脉粥样硬化斑块与血糖波动的关系。方法选择2型糖尿病患者198例,根据颈动脉彩色多普勒超声显像分为无颈动脉硬化组53例( A组)、颈动脉粥样硬化稳定斑块组68例(B组)、颈动脉粥样硬化不稳定斑块组77例(C组)。三组均采用动态血糖监测系统(CGMS)连续监测72 h血糖,计算平均血糖水平( MBG )、日内平均血糖波动幅度( MAGE ),并记录血压、糖化血红蛋白(HbA1c)、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等指标的监测结果。结果三组收缩压、舒张压、FPG、TC、HDL-C、LDL-C、HbA1c比较差异有统计学意义( P<0.05或P<0.01),MBG、MAGE随颈动脉粥样硬化程度逐渐增高( P<0.01)。结论2型糖尿病患者血糖波动会增加颈动脉粥样硬化斑块风险,需重视动态血糖监测。
目的:探討2型糖尿病患者頸動脈粥樣硬化斑塊與血糖波動的關繫。方法選擇2型糖尿病患者198例,根據頸動脈綵色多普勒超聲顯像分為無頸動脈硬化組53例( A組)、頸動脈粥樣硬化穩定斑塊組68例(B組)、頸動脈粥樣硬化不穩定斑塊組77例(C組)。三組均採用動態血糖鑑測繫統(CGMS)連續鑑測72 h血糖,計算平均血糖水平( MBG )、日內平均血糖波動幅度( MAGE ),併記錄血壓、糖化血紅蛋白(HbA1c)、血清總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)等指標的鑑測結果。結果三組收縮壓、舒張壓、FPG、TC、HDL-C、LDL-C、HbA1c比較差異有統計學意義( P<0.05或P<0.01),MBG、MAGE隨頸動脈粥樣硬化程度逐漸增高( P<0.01)。結論2型糖尿病患者血糖波動會增加頸動脈粥樣硬化斑塊風險,需重視動態血糖鑑測。
목적:탐토2형당뇨병환자경동맥죽양경화반괴여혈당파동적관계。방법선택2형당뇨병환자198례,근거경동맥채색다보륵초성현상분위무경동맥경화조53례( A조)、경동맥죽양경화은정반괴조68례(B조)、경동맥죽양경화불은정반괴조77례(C조)。삼조균채용동태혈당감측계통(CGMS)련속감측72 h혈당,계산평균혈당수평( MBG )、일내평균혈당파동폭도( MAGE ),병기록혈압、당화혈홍단백(HbA1c)、혈청총담고순(TC)、감유삼지(TG)、저밀도지단백담고순(LDL-C)、고밀도지단백담고순(HDL-C)등지표적감측결과。결과삼조수축압、서장압、FPG、TC、HDL-C、LDL-C、HbA1c비교차이유통계학의의( P<0.05혹P<0.01),MBG、MAGE수경동맥죽양경화정도축점증고( P<0.01)。결론2형당뇨병환자혈당파동회증가경동맥죽양경화반괴풍험,수중시동태혈당감측。
Objective To study the relationship between the carotid atherosclerotic plaque and blood glucose fluctuations in patients with type 2 diabetes(T2DM).Methods According to the carotid artery color doppler ultra-sonography, 198 patients with T2DM were divided into no carotid sclerosis group (group A, n=53), the stable carot-id atherosclerosis plaque group(group B, n=68), and unstable carotid atherosclerosis plaque group (group C, n=77) .Dynamic glucose monitoring system ( CGMS) was used to continuously monitor 72 h blood sugar , calculate the mean blood glucose(MBG), within-day mean amplitude of glycemic excursion (MAGE), and recorded the age, blood pressure, glycated hemoglobin(HbA1c), serum total cholesterol(TC), triglycerides(TG), low-density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), and gender.Results Among the three groups, there were statistically significant differences in systolic pressure , diastolic blood pressure , FPG, TC, HDL-C, LDL-C and HbA1c, and MBG, MAGE gradually increased with the degree of carotid artery atherosclerosis (all P<0.05). Conclusion In patients with T2DM, the blood sugar fluctuation increases the risk of carotid atherosclerotic plaques , therefore the dynamic blood sugar monitoring should be paid attention to .