中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2015年
9期
31-33
,共3页
原发性高血压%抗高血压药物%应用分析
原髮性高血壓%抗高血壓藥物%應用分析
원발성고혈압%항고혈압약물%응용분석
Essential hypertension%Anti-hypertensive drug%Application Analysis
目的：研究探讨原发性高血压患者抗高血压药物的应用情况，为原发性高血压患者的临床合理用药提供依据。方法：选取我院2013年6月到2014年6月间收治的原发性高血压患者作为研究对象，随机抽取其中的2500例，对其门诊处方进行总结，统计处方中用到的抗高血压药物的种类、名称、用法等情况，并对患者进行追踪随访，调查了解其用药期间血压达标率。结果：2500例患者的处方中，共涉及到钙通道阻滞剂、利尿剂、α1-受体阻滞剂、β-受体阻滞剂、血管紧张素转换酶抑制剂以及血管紧张素受体拮抗剂等六大类14种常用药物，其使用率分别为其使用率分别为44.0%、25.7%、4.0%、6.7%、42.6%、33.5%，其中以钙通道阻滞剂的使用频率最高，种类也最多。在所有14种药物中，又以卡托普利、硝苯地平和吲达帕胺的使用频率最高，分别占22.1%、14.6%、12.3%。其中，单一用药、两种药物联用、三种及以上药物联用的患者分别占55.8%、31.8%、12.4%，以单一用药的患者比例最高，其血压达标率分别为68.0%、70.4%、70.0%，联合用药的血压达标率略高于单一用药，但无统计学差异（P＞0.05）。结论：对原发性高血压患者进行治疗的过程中，要根据患者的身体状况、对不同类别抗高血压药物的敏感程度以及用药中可能引起的不良反应等选择合适的药物类别，通过降低单一抗高血压药物的剂量以及抗高血压药物的联用等方式促进患者的血压达标，促进临床合理用药。
目的：研究探討原髮性高血壓患者抗高血壓藥物的應用情況，為原髮性高血壓患者的臨床閤理用藥提供依據。方法：選取我院2013年6月到2014年6月間收治的原髮性高血壓患者作為研究對象，隨機抽取其中的2500例，對其門診處方進行總結，統計處方中用到的抗高血壓藥物的種類、名稱、用法等情況，併對患者進行追蹤隨訪，調查瞭解其用藥期間血壓達標率。結果：2500例患者的處方中，共涉及到鈣通道阻滯劑、利尿劑、α1-受體阻滯劑、β-受體阻滯劑、血管緊張素轉換酶抑製劑以及血管緊張素受體拮抗劑等六大類14種常用藥物，其使用率分彆為其使用率分彆為44.0%、25.7%、4.0%、6.7%、42.6%、33.5%，其中以鈣通道阻滯劑的使用頻率最高，種類也最多。在所有14種藥物中，又以卡託普利、硝苯地平和吲達帕胺的使用頻率最高，分彆佔22.1%、14.6%、12.3%。其中，單一用藥、兩種藥物聯用、三種及以上藥物聯用的患者分彆佔55.8%、31.8%、12.4%，以單一用藥的患者比例最高，其血壓達標率分彆為68.0%、70.4%、70.0%，聯閤用藥的血壓達標率略高于單一用藥，但無統計學差異（P＞0.05）。結論：對原髮性高血壓患者進行治療的過程中，要根據患者的身體狀況、對不同類彆抗高血壓藥物的敏感程度以及用藥中可能引起的不良反應等選擇閤適的藥物類彆，通過降低單一抗高血壓藥物的劑量以及抗高血壓藥物的聯用等方式促進患者的血壓達標，促進臨床閤理用藥。
목적：연구탐토원발성고혈압환자항고혈압약물적응용정황，위원발성고혈압환자적림상합리용약제공의거。방법：선취아원2013년6월도2014년6월간수치적원발성고혈압환자작위연구대상，수궤추취기중적2500례，대기문진처방진행총결，통계처방중용도적항고혈압약물적충류、명칭、용법등정황，병대환자진행추종수방，조사료해기용약기간혈압체표솔。결과：2500례환자적처방중，공섭급도개통도조체제、이뇨제、α1-수체조체제、β-수체조체제、혈관긴장소전환매억제제이급혈관긴장소수체길항제등륙대류14충상용약물，기사용솔분별위기사용솔분별위44.0%、25.7%、4.0%、6.7%、42.6%、33.5%，기중이개통도조체제적사용빈솔최고，충류야최다。재소유14충약물중，우이잡탁보리、초분지평화신체파알적사용빈솔최고，분별점22.1%、14.6%、12.3%。기중，단일용약、량충약물련용、삼충급이상약물련용적환자분별점55.8%、31.8%、12.4%，이단일용약적환자비례최고，기혈압체표솔분별위68.0%、70.4%、70.0%，연합용약적혈압체표솔략고우단일용약，단무통계학차이（P＞0.05）。결론：대원발성고혈압환자진행치료적과정중，요근거환자적신체상황、대불동유별항고혈압약물적민감정도이급용약중가능인기적불량반응등선택합괄적약물유별，통과강저단일항고혈압약물적제량이급항고혈압약물적련용등방식촉진환자적혈압체표，촉진림상합리용약。
Objective:To study the application of anti-hypertensive drugs to patients with essential hypertension and provide the basis for rational drug use in patients with essential hypertension.Methods:2500 patients with essential hypertension admitted by our hospital from June 2013 to June 2014 were randomly selected as the research objects.Their outpatient prescriptions were summarized.The type, name, usage, etc.of anti-hypertensive drugs in the prescriptions were statistically analyzed.The patients were followed up and their blood pressure during the treatment were investigated.Results:Six categories and 14 kinds of commonly used drugs including calcium channel blockers, diuretics,α1- blockers,β- blockers, angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists were involved in the prescriptions of the 2500 patients.The utilization rate of the above six categories drugs were respectively 44.0%,25.7%,4.0%,6.7%, 42.6%,33.5%,of which the highest was calcium channel blockers.In the utilization rate of all 14 kinds of drugs,the top three were captopril, nifedipine and indapamide.Their utilization rate were respectively 22.1%,14.6% and 12.3%.Patients with one kind of drug, two kinds of drugs and more than three drugs respectively accounted for 55.8%,31.8% and 12.4%.Patients with one kind of drug accounted the highest proportion. The rate of reaching standard of blood pressure of the above three kinds of patients were respectively 68.0%,70.4% and 70.0%. The rates of reaching standard of blood pressure of patients with combination of drugs were slightly higher than that with single drug, but there was no significant difference (P>0.05).Conclusion:In the treatment of patients with essential hypertension, drug categories should be chosen according to the physical condition and sensitivity to different categories of anti-hypertensive drugs of the patient and adverse reactions caused by drugs. The rates of reaching standard of blood pressure should be improved by reducing the dose of single use of anti-hypertensive drugs and combination of anti-hypertensive drugs,so as to promote rational drug use.
